iASPP, A potential drug target in cancer therapy

被引：10

作者：

Gillotin, Sebastien ^{[1
]}

机构：

[1] Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 09期

关键词：

MESSENGER-RNA EXPRESSION; CELL LINES; P53; ASPP; PROTEINS; LEUKEMIA; ISOFORM; MEMBERS; 53BP2; DEATH;

D O I：

10.1016/j.leukres.2009.04.037

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1175 / 1177

页数：3

共 19 条

[1] ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia [J].

Agirre, X ;

Román-Gómez, J ;

Jiménez-Velasco, A ;

Garate, L ;

Montiel-Duarte, C ;

Navarro, G ;

Vázquez, I ;

Zalacain, M ;

Calasanz, MJ ;

Heiniger, A ;

Torres, A ;

Minna, JD ;

Prósper, F .

ONCOGENE, 2006, 25 (13) :1862-1870

[2]

AHN J, 2009, J BIOL CHEM

[3] ASPP1 and ASPP2: Common activators of p53 family members [J].

Bergamaschi, D ;

Samuels, Y ;

Jin, BQ ;

Duraisingham, S ;

Crook, T ;

Lu, X .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :1341-1350

[4] iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human [J].

Bergamaschi, D ;

Samuels, Y ;

O'Neil, NJ ;

Trigiante, G ;

Crook, T ;

Hsieh, JK ;

O'Connor, DJ ;

Zhong, S ;

Campargue, I ;

Tomlinson, ML ;

Kuwabara, PE ;

Lu, X .

NATURE GENETICS, 2003, 33 (02) :162-167

[5] MICE DEFICIENT FOR P53 ARE DEVELOPMENTALLY NORMAL BUT SUSCEPTIBLE TO SPONTANEOUS TUMORS [J].

DONEHOWER, LA ;

HARVEY, M ;

SLAGLE, BL ;

MCARTHUR, MJ ;

MONTGOMERY, CA ;

BUTEL, JS ;

BRADLEY, A .

NATURE, 1992, 356 (6366) :215-221

[6] Expression of the RAI gene is conducive to apoptosis:: Studies of induction and interference [J].

Laska, Magdalena J. ;

Strandbygard, Dorthe ;

Kjeldgaard, Anette ;

Mains, Mette ;

Corydon, Thomas J. ;

Memon, Ashfaque A. ;

Sorensen, Boe S. ;

Vogel, Ulla ;

Jensen, Uffe B. ;

Nexo, Bjorn A. .

EXPERIMENTAL CELL RESEARCH, 2007, 313 (12) :2611-2621

[7] Downregulated mRNA expression of ASPP and the hypermethylation of the 5′-untranslated region in cancer cell lines retaining wild-type p53 [J].

Liu, ZJ ;

Lu, X ;

Zhang, Y ;

Zhong, S ;

Gu, SZ ;

Zhang, XB ;

Yang, X ;

Xin, HM .

FEBS LETTERS, 2005, 579 (07) :1587-1590

[8] Abnormal mRNA expression of ASPP members in leukemia cell lines [J].

Liu, ZJ ;

Zhang, Y ;

Zhang, XB ;

Yang, X .

LEUKEMIA, 2004, 18 (04) :880-880

[9] p53: a heavily dictated dictator of life and death [J].

Lu, X .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (01) :27-33

[10] Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPPIRI3L/iASPP [J].

Nexo, Bjorn A. ;

Vogel, Ulla ;

Olsen, Anja ;

Nyegaard, Mette ;

Bukowy, Zuzanna ;

Rockenbauer, Eszter ;

Zhang, Xiuqing ;

Koca, Cemile ;

Mains, Mette ;

Hansen, Bettina ;

Hedemand, Anne ;

Kjeldgaard, Anette ;

Laska, Magdalena J. ;

Raaschou-Nielsen, Ole ;

Cold, Soren ;

Overvad, Kim ;

Tjonneland, Anne ;

Bolund, Lars ;

Borglum, Anders D. .

BMC MEDICAL GENETICS, 2008, 9

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