Visible-Light-Promoted Asymmetric Cross-Dehydrogenative Coupling of Tertiary Amines to Ketones by Synergistic Multiple Catalysis

被引：228

作者：

Yang, Qi ^{[1
,2
]}

Zhang, Long ^{[1
,2
]}

Ye, Chen ^{[3
]}

Luo, Sanzhong ^{[1
,2
]}

Wu, Li-Zhu ^{[3
]}

Tung, Chen-Ho ^{[3
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 13期

关键词：

amines; cross-coupling; hydrogen; photochemistry; reaction mechanisms; C-H BONDS; MERGING PHOTOREDOX CATALYSIS; DUAL CATALYSIS; BETA-KETOCARBONYLS; MOLECULAR-OXYGEN; COMBINING PHOTOREDOX; ACID; ACTIVATION; CASCADE; ALKYLATION;

D O I：

10.1002/anie.201700572

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reported herein is an unprecedented photocatalytic asymmetric cross-dehydrogenative coupling reaction between tertiary amines and simple ketones, and it proceeds by synergistic multiple catalysis with substoichiometric amounts of a hydrogen acceptor. This process is enabled by a simple chiral primary amine catalyst through the coupling of a catalytic enamine intermediate and an iminium cation intermediate in situ generated from tetrahydroisoquinoline derivatives by coupled Ru/Co catalysis.

引用

页码：3694 / 3698

页数：5

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