A general synthesis of enantiopure 1,2-aminoalcohols via chiral morpholinones

被引：25
|
作者：
Segat-Dioury, F [1 ]
Lingibé, O [1 ]
Graffe, B [1 ]
Sacquet, MC [1 ]
Lhommet, G [1 ]
机构：
[1] Univ Paris 06, CNRS, Lab Chim Heterocycles, F-75252 Paris 05, France
来源：
TETRAHEDRON | 2000年 / 56卷 / 02期
关键词：
aminoalcohols; asymmetric induction; reduction; imines;
D O I：
10.1016/S0040-4020(99)00935-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Eleven optically active 1,2-aminoalcohols 20a-i and 26b-c were prepared from D-phenylglycine via cyclic imines 7b-i (or enamine 7a). The key step of the strategy is the diastereoselective reduction of chiral oxazinones 7a-i. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：233 / 248
页数：16
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