Hitting the Bull's Eye: Novel Directed Cancer Therapy Through Helicase-Targeted Synthetic Lethality

被引：22

作者：

Aggarwal, Monika ^{[1
]}

Brosh, Robert M., Jr. ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2009年 / 106卷 / 05期

关键词：

SYNTHETIC LETHALITY; HELICASE; CANCER THERAPY; DNA REPAIR; ANTI-CANCER DRUG; BOX DNA HELICASE; HOMOLOGOUS RECOMBINATION; MUS81; ENDONUCLEASE; REPAIR; BLM; REPLICATION; NEUROSPORA; PROTEINS; ABSENCE; DAMAGE;

D O I：

10.1002/jcb.22048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Designing strategies for anti-cancer therapy have posed a significant challenge. One approach has been to inhibit specific DNA repair proteins and their respective pathways to enhance chemotherapy and radiation therapy used to treat cancer patients. Synthetic lethality represents an approach that exploits pre-existing DNA repair deficiencies in certain tumors to develop inhibitors of DNA repair pathways that compensate for the tumor-associated repair deficiency. Since helicases play critical roles in the DNA damage response and DNA repair, particularly in actively dividing and replicating cells, it is proposed that the identification and characterization of synthetic lethal relationships of DNA helicases will be of value in developing improved anti-cancer treatment strategies. In this review, we discuss this hypothesis and current evidence for synthetic lethal interactions of eukaryotic DNA helicases in model systems. J. Cell. Biochem. 106: 758-763, 2009. Published 2009 Wiley-Liss, Inc.

引用

页码：758 / 763

页数：6

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