Scedosporium prolificans Endocarditis: Case Report and Literature Review

被引：10

作者：

Wakabayashi, Yoshitaka ^{[1
]}

Okugawa, Shu ^{[1
,2
]}

Tatsuno, Keita ^{[1
,2
]}

Ikeda, Mahoko ^{[1
,2
]}

Misawa, Yoshiki ^{[2
]}

Koyano, Saho ^{[2
]}

Tsuji, Eiichi ^{[3
]}

Yanagimoto, Shintaro ^{[1
]}

Hatakeyama, Shuji ^{[1
]}

Moriya, Kyoji ^{[2
]}

Yotsuyanagi, Hiroshi ^{[1
]}

机构：

[1] Univ Tokyo, Dept Infect Dis, Tokyo 1138654, Japan

[2] Univ Tokyo, Dept Infect Control & Prevent, Tokyo 1138654, Japan

[3] Tokyo Univ Hosp, Dept Gastrointestinal Surg Metab Care & Endocrine, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 01期

关键词：

Scedosporium prolificans; Endocarditis; beta-D glucan; fungal infection; INFECTIVE ENDOCARDITIS; INFLATUM; TRANSPLANTATION; COMBINATIONS; PATIENT; MYCOSIS;

D O I：

10.2169/internalmedicine.55.5592

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Scedosporium prolificans, a hyaline filamentous fungus, is widely distributed in the environment and is currently an emerging human pathogen, especially among immunocompromised patients. However, S. prolificans endocarditis is rare. We herein report a case of S. prolificans endocarditis in a 64-year-old patient with breast cancer in complete remission for 30 years after chemotherapy and radiation treatment who was not cured. Susceptibility testing showed resistance to all antifungal drugs, except echinocandin. A review of the literature revealed 10 cases of S. prolificans endocarditis; of these, only one involved an immunocompetent host with no risk factors and only two patients survived. In order to improve the mortality rate, it is necessary to establish rapid diagnostic methods and efficient therapeutic approaches.

引用

页码：79 / 82

页数：4

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