Metallacarboranes as Labels for Multipotential Electrochemical Coding of DNA. [3-Chromium bis(dicarbollide)](-1)ate and Its Nucleoside Conjugates

被引：14

作者：

Olejniczak, Agnieszka B. ^{[1
]}

Gruner, Bohumir ^{[2
]}

Sicha, Vaclav ^{[2
]}

Broniarek, Sabina ^{[1
]}

Lesnikowski, Zbigniew J. ^{[1
]}

机构：

[1] Polish Acad Sci, Lab Mol Virol & Biol Chem, Inst Med Biol, PL-93232 Lodz, Poland

[2] Area Res Inst 1001, AS CR, Inst Inorgan Chem, Husinec Rez 25068, Czech Republic

来源：

ELECTROANALYSIS | 2009年 / 21卷 / 3-5期

关键词：

Redox labels; Electrochemical coding; Metallacarboranes; Nucleosides; DNA; TRIPHOSPHATES; DERIVATIVES; PLATFORM; CARBON;

D O I：

10.1002/elan.200804434

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Metallacarborane bearing chromium is proposed as the electrochemical label for electrochemical coding of DNA. Synthesis and HDV characteristics of 2'-deoxyadenosine (dA) containing [(3,3'-chromium-1,2,1',2'-dicarbollide)] (-1)]ate complex are described. The proposed labeling of nucleosides, together with previously described nucleoside/metallacarborane conjugates bearing cobalt and iron lay the foundations for multipotential electrochemical coding of DNA with metallacarborane complexes and simultaneous detection of several DNA targets.

引用

页码：501 / 506

页数：6

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