Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy

被引：40
|
作者：
Trieb, K
Gerth, R
Holzer, G
Grohs, JG
Berger, P
Kotz, R
机构：
[1] Univ Vienna, Dept Orthoped, A-1090 Vienna, Austria
[2] Austrian Acad Sci, Inst Biomed Aging Res, Innsbruck, Austria
来源：
BRITISH JOURNAL OF CANCER | 2000年 / 82卷 / 01期
关键词：
osteosarcoma; heat shock protein 90; antibody; human; ELISA;
D O I：
10.1054/bjoc.1999.0881
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better response to neoadjuvant chemotherapy (P < 0.01), whereas the absence correlated with development of metastases. These data suggest that anti-Hsp90 antibodies might be of predictive value in human osteosarcoma. (C) 2000 Cancer Research Campaign.
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收藏
页码：85 / 87
页数：3
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