Cyclic peptide alkaloids from the bark of Discaria americana

被引：27

作者：

Giacomelli, SR ^{[1
]}

Maldaner, G ^{[1
]}

Gonzaga, WA ^{[1
]}

Garcia, CM ^{[1
]}

da Silva, UF ^{[1
]}

Dalcol, II ^{[1
]}

Morel, AF ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 07期

关键词：

Discaria americana; Rhamnaceae; cyclic peptides; antibacterial activity;

D O I：

10.1016/j.phytochem.2004.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isolation and structure determination of cyclic peptide alkaloids, discarine-M and discarine-N, along with seven known cyclic peptide alkaloids, adouetine-Y', franganine, frangulanine, discarines-A, -B, -C, and -D from the root bark of Discaria americana are described. Structures were determined spectroscopically, especially using 2D NMR spectroscopic analysis. The crude methanol extract, the basic ether extract, and the alkaloids 6 and 7 also weakly inhibited growth of gram-negative and gram-positive bacteria. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：933 / 937

页数：5

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