Antioxidant and cytotoxic activities investigation of tomato seed extracts

被引：9

作者：

Tommonaro, Giuseppina ^{[1
]}

Caporale, Angelamaria ^{[2
]}

De Martino, Laura ^{[2
]}

Popolo, Ada ^{[2
]}

De Prisco, Rocco ^{[1
]}

Nicolaus, Barbara ^{[1
]}

Abbamondi, Gennaro Roberto ^{[1
]}

Saturnino, Carmela ^{[2
]}

机构：

[1] Natl Res Council Italy, Inst Biomol Chem, I-80078 Pozzuoli, NA, Italy

[2] Univ Salerno, Dept Farmacy, I-84084 Fisciano, SA, Italy

来源：

NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 10期

关键词：

Tomato; antioxidant activity; cytotoxicity; seed extracts; PREVENTION; LYCOPENE; CANCER;

D O I：

10.1080/14786419.2013.879474

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Biological activities of different varieties of tomato seed extracts were evaluated to verify the potential antioxidant and/or antiproliferative activity of the bioactive metabolites present in them. Findings demonstrated that among all the varieties investigated (San Marzano Rosso, San Marzano Giallo, Corbarino, Black Tomato and San Marzano/Black Tomato hybrid) San Marzano Rosso seed extract exhibited the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition, and the best cytotoxic activity evaluated by using the brine shrimp test (LD50: 23,198ppm) and 3-(4,5-dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazolium bromide assay on A375 cell line (IC50: 137.7g/mL).

引用

页码：764 / 768

页数：5

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