Antioxidant and cytotoxic activities investigation of tomato seed extracts

被引：9
|
作者：
Tommonaro, Giuseppina [1 ]
Caporale, Angelamaria [2 ]
De Martino, Laura [2 ]
Popolo, Ada [2 ]
De Prisco, Rocco [1 ]
Nicolaus, Barbara [1 ]
Abbamondi, Gennaro Roberto [1 ]
Saturnino, Carmela [2 ]
机构：
[1] Natl Res Council Italy, Inst Biomol Chem, I-80078 Pozzuoli, NA, Italy
[2] Univ Salerno, Dept Farmacy, I-84084 Fisciano, SA, Italy
来源：
NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 10期
关键词：
Tomato; antioxidant activity; cytotoxicity; seed extracts; PREVENTION; LYCOPENE; CANCER;
D O I：
10.1080/14786419.2013.879474
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Biological activities of different varieties of tomato seed extracts were evaluated to verify the potential antioxidant and/or antiproliferative activity of the bioactive metabolites present in them. Findings demonstrated that among all the varieties investigated (San Marzano Rosso, San Marzano Giallo, Corbarino, Black Tomato and San Marzano/Black Tomato hybrid) San Marzano Rosso seed extract exhibited the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition, and the best cytotoxic activity evaluated by using the brine shrimp test (LD50: 23,198ppm) and 3-(4,5-dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazolium bromide assay on A375 cell line (IC50: 137.7g/mL).
引用
收藏
页码：764 / 768
页数：5
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