Bone marrow stromal cells can achieve cure of chronic paraplegic rats: Functional and morphological outcome one year after transplantation

被引：120

作者：

Zurita, Mercedes ^{[1
]}

Vaquero, Jesus ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Puerta Hierro Hosp, Neurosurg Serv, Mapfre Med Fdn,Neurosci Res Unit, Madrid 28035, Spain

来源：

NEUROSCIENCE LETTERS | 2006年 / 402卷 / 1-2期

关键词：

spinal cord injury; adult stem cells; paraplegia;

D O I：

10.1016/j.neulet.2006.03.069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic paraplegia resulting from severe spinal cord injury (SCI) is considered to be an irreversible condition. Nevertheless, recent studies utilizing adult stem cells appear to offer promise in the treatment of this and other neurological diseases. Here, we show that progressive functional motor recovery is achieved over the course of the year following the administration of bone marrow stromal cells (BMSC) in traumatic central spinal cord cavities of adult rats with chronic paraplegia. At this time, functional recovery is almost complete and associated with evident nervous tissue regeneration in the previously injured spinal cord. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 56

页数：6

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