Regulation of LRP-1 expression: Make the point

被引：37
作者：
Emonard, H. [1 ]
Theret, L. [1 ]
Bennasroune, A. H. [1 ]
Dedieu, S. [1 ]
机构：
[1] Univ Reims, UFR Sci Exactes & Nat, Unite MEDyC Matrice Extracellulaire & Dynam Cellu, CNRS,UMR 7369, F-51687 Reims 2, France
来源：
PATHOLOGIE BIOLOGIE | 2014年 / 62卷 / 02期
关键词：
LRP-1; Endocytosis; Signaling; Shedding; RECEPTOR-RELATED PROTEIN; BLOOD-BRAIN-BARRIER; ALPHA(2)-MACROGLOBULIN RECEPTOR; ALPHA-2-MACROGLOBULIN RECEPTOR; PLASMINOGEN-ACTIVATOR; TYROSINE PHOSPHORYLATION; DECREASED EXPRESSION; POSSIBLE INVOLVEMENT; CELL-MIGRATION; HUMAN PROSTATE;
D O I：
10.1016/j.patbio.2014.02.002
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface. (C) 2014 Elsevier Masson SAS. All rights reserved.
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页码：84 / 90
页数：7
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