IL-2-inducible T-cell kinase (ITK) finds another (dance) partner ... TFII-I

被引：5

作者：

August, Avery ^{[1
]}

机构：

[1] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 09期

关键词：

ITK; T-cell signaling; Tec kinase; TFII-I; BRUTONS TYROSINE KINASE; TEC FAMILY; REGULATES INDUCTION; IGE PRODUCTION; CALCIUM-ENTRY; ACTIVE ITK; ACTIVATION; DEFICIENT; GAMMA; MICE;

D O I：

10.1002/eji.200939813

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.

引用

页码：2354 / 2357

页数：4

共 50 条

[1] Successful hematopoietic stem cell trasnplantation in children with IL-2-inducible T-cell Kinase (ITK) deficiency
Kuskonmaz, B.
Ayvaz, D.
Erman, B.
Hanoglu, D.
Tavil, B.
Aydin, B.
Akyuz, C.
Sanal, O.
Tezcan, I.
Uckan, D.
BONE MARROW TRANSPLANTATION, 2016, 51 : S257 - S257
[2] IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach
Stepensky, Polina
Weintraub, Michael
Yanir, Asaf
Revel-Vilk, Shoshana
Krux, Frank
Huck, Kirsten
Linka, Rene M.
Shaag, Avraham
Elpeleg, Orly
Borkhardt, Arndt
Resnick, Igor B.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (03): : 472 - 476
[3] Inhibition of IL2-Inducible T-Cell Kinase (ITK)-Mediated Chemoresistance By Ibrutinib in T-Cell Lymphoproliferative Disorders
Wang, Tianjiao
Lu, Ye
Polk, Avery
Zamalloa, Carlos Murga
Wilcox, Ryan A.
BLOOD, 2015, 126 (23)
[4] Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization
Tate, G
Okuyama, M
Okamoto, M
Futaki, G
Kimura, S
Endo, Y
Mitsuya, T
Katagiri, M
CYTOGENETICS AND CELL GENETICS, 1996, 74 (1-2): : 96 - 98
[5] Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase
Joseph, Raji E.
Ginder, Nathaniel D.
Hoy, Julie A.
Nix, Jay C.
Honzatko, Richard B.
Andreotti, Amy H.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 67 : 269 - 273
[6] IL-2-Inducible T Cell Kinase Tunes T Regulatory Cell Development and Is Required for Suppressive Function
Huang, Weishan
Jeong, Ah-Reum
Kannan, Arun K.
Huang, Lu
August, Avery
JOURNAL OF IMMUNOLOGY, 2014, 193 (05): : 2267 - 2272
[7] The tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses
Iyer, Archana S.
August, Avery
JOURNAL OF IMMUNOLOGY, 2008, 180 (12): : 7869 - 7877
[8] Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells
Sacristan, Catarina
Schattgen, Stefan A.
Berg, Leslie J.
Bunnell, Stephen C.
Roy, Ananda L.
Rosenstein, Yvonne
EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (09) : 2584 - 2595
[9] Interleukin-2-Inducible T-Cell Kinase (ITK) Inhibitors for the Treatment of T-Cell Lymphoproliferative Disorders
Reneau, John C.
Hwang, Steven R.
Murga-Zamalloa, Carlos A.
Buggy, Joseph J.
Janc, James W.
Wilcox, Ryan A.
BLOOD, 2018, 132
[10] CD28-Y218 phosphorylation in CAR-T cells is mediated by the IL-2-inducible Tcell kinase (ITK)
Martinez-Planes, Elena
Fontela, Miguel G.
Ramello, Cecilia
Abate-Daga, Daniel
CANCER RESEARCH, 2023, 83 (07)

← 1 2 3 4 5 →