Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa

被引：97

作者：

Thorner, Anna R.

Vogels, Ronald

Kaspers, Jorn

Weverling, Gerrit J.

Holterman, Lennart

Lemckert, Angelique A. C.

Dilraj, Athmanundh

McNally, Lisa M.

Jeena, Prakash M.

Jepsen, Soren

Abbink, Peter

Nanda, Anjali

Swanson, Patricia E.

Bates, Andrew T.

O'Brien, Kara L.

Havenga, Menzo J. E.

Goudsmit, Jaap

Barouch, Dan H.

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02215 USA

[2] Crucell Holland BV, Leiden, Netherlands

[3] S African MRC, Durban, South Africa

[4] Univ KwaZulu Natal, Durban, South Africa

[5] European Malaria Vaccine Initiat, Copenhagen, Denmark

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 10期

关键词：

D O I：

10.1128/JCM.01249-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type I and other pathogens.

引用

页码：3781 / 3783

页数：3

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