Synthesis of new pyrimido[4,5-d]pyrimidine derivatives from 5-acetyl-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones and guanidine

被引：3

作者：

Komkov, A. V. ^{[1
]}

Baranin, S. V. ^{[1
]}

Dorokhov, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 02期

关键词：

diacetylketene N; S-acetal; isothiocyanates; 5-acetyl-6-methyl-4-methyl-sulfanylpyrimidine-2(1H)-thiones; guanidine; condensation; 7-amino-5-methyl-4-methylidene-3,4-dihydropyrimido[4,5-dipyrimidine-2(1H)-thiones; 4-alkoxy-7-amino-4,5-dimethyl-3,4-dihydropyrimido [4,5-d] pyrimidine-2 ( 1H) -thiones; 5-acetyl-1-aryl(alkyl)-6-methyl-2-thiouracils; BETA-DICARBONYL COMPOUNDS; N; S-ACETALS; DIACETYLKETENE;

D O I：

10.1007/s11172-014-0454-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactions of 5-acetyl-1-aryl(alkyl)-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones (prepared from diacetylketene N,S-acetal) with guanidine afforded 3-alkyl- and 3-ary1-7amino-5-methy1-4-methylidene-3,4-dihydropyrimido [4,5-c] pyrimidine -2 (1H)-thiones. Byproducts of these reactions (5-acetyl-1-alkyl(ary1)-6-methyl-2-thiouracils) can also be obtained from the starting pyrimidinethiones and Et0Na in Et0H. Pyrimidopyrimidinethiones can react with Me0H at the methylidene group in the presence of MeONa.

引用

页码：469 / 474

页数：6

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