In vitro Cytotoxicity Activity of Platinum(II) Complexes with Alkyl-branched/Cyclic Alkoxyacetates as Leaving Ligands

被引：0
|
作者：
Liu Xia [1 ]
Gou Shao-Hua [1 ,2 ]
Shen Hong [1 ]
Zhu Hai-Bin [2 ]
Zheng He-Gen [1 ]
机构：
[1] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China
来源：
CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2009年 / 25卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Pt (II) complexes; anti-tumor activity; alkyl-branched alkoxycarboxylates; TRADITIONAL CHINESE MEDICINE; ANTITUMOR-ACTIVITY; INNOVATIVE COMBINATION; CISPLATIN ANALOGS; CARBOPLATIN; SERIES; AGENTS;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Twelve cisplatin-typed platinium complexes containing alkyl-branched alkoxyacetates and cyclic alkoxyacetates as leaving groups were prepared and characterized by elemental analysis, infrared, electro-spray ionization MS and H-1 NMR spectroscopy. All compounds were evaluated for their in vitro cytotoxicity against A549 human non-small-cell lung cancer, BEL-7402 human hepatocellular carcinoma and MCF-7 human breast cancer cell lines, respectively. 5 out of 12 complexes with alkyl-branched alkoxyacetates showed good cytotoxicity against MCF-7 cell line. Complex 2{cis-(diammine)bis(t-butoxyacetate)platinum(II)} showed the highest cytotoxicity against all the three cell lines.
引用
收藏
页码：700 / 707
页数：8
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