Maternal antibodies and infant immune responses to vaccines

被引：90

作者：

Edwards, Kathryn M. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Res Program, Sarah H Sell & Cornelius Vanderbilt Chair Pediat, Nashville, TN 37232 USA

来源：

VACCINE | 2015年 / 33卷 / 47期

关键词：

Maternal antibody; Transplacental transfer; Vaccine responses; Inhibition of vaccine responses; MEASLES VACCINATION; PRIMARY IMMUNIZATION; MUMPS VACCINATION; RURAL SENEGAL; AGE; CHILDREN; IMMUNOGENICITY; IMMUNOGLOBULIN; MORTALITY; INFECTION;

D O I：

10.1016/j.vaccine.2015.07.085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infants are born with immature immune systems, making it difficult for them to effectively respond to the infectious pathogens encountered shortly after birth. Maternal antibody is actively transported across the placenta and serves to provide protection to the newborn during the first weeks to months of life. However, maternal antibody has been shown repeatedly to inhibit the immune responses of young children to vaccines. The mechanisms for this inhibition are presented and the impact on ultimate immune responses is discussed. (C) 2015 The Author. Published by Elsevier Ltd.

引用

页码：6469 / 6472

页数：4

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