Obesity Negatively Impacts Lung Function in Children and Adolescents

被引:90
作者
Davidson, Warren J. [1 ]
Mackenzie-Rife, Kelly A. [2 ]
Witmans, Manisha B. [3 ]
Montgomery, Mark D. [1 ]
Ball, Geoff D. C. [3 ]
Egbogah, Shirley [4 ]
Eves, Neil D. [1 ,5 ]
机构
[1] Univ Calgary, Fac Med, Calgary, AB, Canada
[2] North Isl Coll, Dept Math & Sci, Courtenay, BC, Canada
[3] Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada
[4] Univ Alberta, Edmonton, AB, Canada
[5] Univ British Columbia, Fac Hlth & Social Dev, Ctr Heart Lung & Vasc Hlth, Kelowna, BC V1V 1V7, Canada
基金
加拿大健康研究院;
关键词
body weight; pulmonary function tests; youth; BODY-MASS INDEX; PULMONARY-FUNCTION; BREATHING DISORDERS; CHILDHOOD OBESITY; FAT DISTRIBUTION; MORBIDLY OBESE; OVERWEIGHT; ASTHMA; STANDARDIZATION; VOLUME;
D O I
10.1002/ppul.22915
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
ObjectivesTo investigate the relationship between weight status (body mass index [BMI] percentile and BMI z-score) and lung volumes in healthy children and adolescents. HypothesesWe hypothesized that: (a) there would be a significant inverse relationship between age- and sex-specific BMI distribution and functional residual capacity (FRC), and expiratory reserve volume (ERV), respectively; and (b) obese children would have significantly reduced FRC and ERV compared to their non-obese peers. MethodsThe medical records of all individuals who successfully performed pulmonary function testing between 2000 and 2007 at two university children's hospitals were reviewed. Participants were excluded if they had cardiopulmonary, neuromuscular, or chest wall disease. ResultsOf 1,469 record reviewed, 327 subjects met study criteria. Percent predicted ERV was lowest in the obese group (P<0.001) while residual volume (RV) was lowest in the overweight and obese groups (P<0.001). Underweight participants had a lower percent predicted forced vital capacity (FVC) (P=0.027) and vital capacity (VC; P=0.039). Obese participants had the lowest FEV1/FVC (P<0.001). A positive linear relationship existed between BMI z-score and percent predicted FVC, VC, and diffusing capacity of carbon monoxide (DLCO). A negative linear relationship was found between BMI z-score and percent predicted FRC, ERV, RV, and absolute FEV1/FVC. ConclusionsOur results show that increasing weight status in children and adolescents is associated with a general reduction in lung volume measurements, which may reflect impaired lung function, increased respiratory symptoms, and decreased functional status. Pediatr Pulmonol. 2014; 49:1003-1010. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:1003 / 1010
页数:8
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