Ion channels - Gate expectations

被引:28
作者
Garcia, ML [1 ]
机构
[1] Merck Res Labs, Dept Ion Channels, Rahway, NJ 07065 USA
关键词
D O I
10.1038/430153a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The opening and closing — gating — of ion channels in response to specific stimuli is crucial for cell function. The membrane-partitioning activities of two venom toxins give insights into the mechanisms involved.
引用
收藏
页码:153 / 155
页数:3
相关论文
共 10 条
[1]   Stirring up controversy with a voltage sensor paddle [J].
Ahern, CA ;
Horn, R .
TRENDS IN NEUROSCIENCES, 2004, 27 (06) :303-307
[2]  
Ashcroft F.M., 2000, Ion Channels and Disease
[3]   The principle of gating charge movement in a voltage-dependent K+ channel [J].
Jiang, YX ;
Ruta, V ;
Chen, JY ;
Lee, A ;
MacKinnon, R .
NATURE, 2003, 423 (6935) :42-48
[4]   X-ray structure of a voltage-dependent K+ channel [J].
Jiang, YX ;
Lee, A ;
Chen, JY ;
Ruta, V ;
Cadene, M ;
Chait, BT ;
MacKinnon, R .
NATURE, 2003, 423 (6935) :33-41
[5]   Interaction between extracellular hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels [J].
Lee, HC ;
Wang, JM ;
Swartz, KJ .
NEURON, 2003, 40 (03) :527-536
[6]   A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom [J].
Lee, SY ;
MacKinnon, R .
NATURE, 2004, 430 (6996) :232-235
[7]   Functional analysis of an archaebacterial voltage-dependent K+ channel [J].
Ruta, V ;
Jiang, YX ;
Lee, A ;
Chen, JY ;
MacKinnon, R .
NATURE, 2003, 422 (6928) :180-185
[8]   Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers [J].
Suchyna, TM ;
Tape, SE ;
Koeppe, RE ;
Andersen, OS ;
Sachs, F ;
Gottlieb, PA .
NATURE, 2004, 430 (6996) :235-240
[9]   Molecular surface of tarantula toxins interacting with voltage sensors in Kv channels [J].
Wang, JM ;
Roh, SH ;
Kim, S ;
Lee, CW ;
Kim, JI ;
Swartz, KJ .
JOURNAL OF GENERAL PHYSIOLOGY, 2004, 123 (04) :455-467
[10]   A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels [J].
Winterfield, JR ;
Swartz, KJ .
JOURNAL OF GENERAL PHYSIOLOGY, 2000, 116 (05) :637-644