BDNF 196 G/A and COMT Val158Met Polymorphisms and Susceptibility to ADHD: A Meta-Analysis

被引：18
作者：
Lee, Young Ho [1 ]
Song, Gwan Gyu [1 ]
机构：
[1] Korea Univ, Coll Med, Seoul, South Korea
来源：
JOURNAL OF ATTENTION DISORDERS | 2018年 / 22卷 / 09期
关键词：
ADHD; BDNF; COMT; polymorphism; meta-analysis; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NEUROTROPHIC FACTOR GENE; ASSOCIATION; POPULATION; CHILDREN;
D O I：
10.1177/1087054715570389
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: The aim of this study was to determine whether the brain-derived neurotrophic factor (BDNF) 196 G/A or catechol-O-methyltransferase (COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD. Results: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p = .638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196), European or Asian population. Conclusion: This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.
引用
收藏
页码：872 / 877
页数：6
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