Antioxidant levels, copper and zinc concentrations were associated with postpartum luteal activity, pregnancy loss and pregnancy status in Holstein dairy cows

被引:11
作者
Nazari, Alireza [1 ]
Dirandeh, Essa [1 ]
Ansari-Pirsaraei, Zarbakht [1 ]
Deldar, Hamid [1 ]
机构
[1] Sari Agr Sci & Nat Resources Univ, Dept Anim Sci, POB 578, Sari, Mazandaran, Iran
关键词
Dairy cow; Fertility; Reactive oxygen species; Trace minerals; Ultrasonography; OXIDATIVE STRESS; DIFFERENT PATTERNS; INFERTILITY; IMMUNITY; CELLS;
D O I
10.1016/j.theriogenology.2019.04.034
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The role of oxidative stress in the control of female reproduction has not been fully elucidated in ruminants; however, it seems that antioxidants can make influence to the reproductive axis at different levels. Therefore, the aim of this study was to determine the relationship between antioxidant status and concentrations of trace minerals (chromium (Cr), copper (Cu), iron (Fe), and zinc (Zn)) with postpartum luteal activity and fertility in Holstein dairy cows. The cows (n = 100, a parity range of 2-5, and a body condition score (BCS) of 3.0 +/- 0.25, mean +/- SEM) were assigned to the experiment at second week post calving. Ovarian follicular dynamics were monitored twice a week (from 3rd to 6th weeks post calving) by transrectal ultrasonography (US). Blood samples were collected twice weekly from the 3rd to the 6th weeks post calving at timed artificial insemination (TAI), and days 32 and 50 post AI to determine superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), and trace mineral concentrations. There were associations between plasma concentrations of SOD, GPX, and TAC with postpartum luteal activity (PLA, P = 0.01) and ovulation (P = 0.03). Mean plasma SOD and GPX activities and TAC levels (U/mL) were greater in cows with normal luteal activity (NLA) than prolonged luteal phase (PLP) and anovulation (AO) cows, as well as in ovulated compared to AO cows (P = 0.03). Pregnant cows had greater levels of SOD, GPX, and TAC (U/mL) at TAI than non-pregnant cows (P = 0.01). Plasma Cu and Zn concentrations increased in pregnant compared to non-pregnant cows at TAI. In conclusion, antioxidant levels and Cu and Zn concentrations were associated with PLA and fertility. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码:97 / 103
页数:7
相关论文
共 32 条
  • [1] Dietary conjugated linoleic acid supplementation alters the expression of genes involved in the endocannabinoid system in the bovine endometrium and increases plasma progesterone concentrations
    Abolghasemi, A.
    Dirandeh, E.
    Pirsaraei, Z. Ansari
    Shohreh, B.
    [J]. THERIOGENOLOGY, 2016, 86 (06) : 1453 - 1459
  • [2] Oxidative stress and its implications in female infertility - a clinician's perspective
    Agarwal, A
    Gupta, S
    Sharma, R
    [J]. REPRODUCTIVE BIOMEDICINE ONLINE, 2005, 11 (05) : 641 - 650
  • [3] The effects of oxidative stress on female reproduction: a review
    Agarwal, Ashok
    Aponte-Mellado, Anamar
    Premkumar, Beena J.
    Shaman, Amani
    Gupta, Sajal
    [J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2012, 10
  • [4] Antioxidative signalling pathways regulate the level of reactive oxygen species at the endometrial-extraembryonic membranes interface during early pregnancy
    Al-Gubory, Kais H.
    Garrel, Catherine
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (09) : 1511 - 1518
  • [5] Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status?
    Argüelles, S
    García, S
    Maldonado, M
    Machado, A
    Ayala, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2004, 1674 (03): : 251 - 259
  • [6] Oxidative stress and the ovary
    Behrman, HR
    Kodaman, PH
    Preston, SL
    Gao, SP
    [J]. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2001, 8 (01) : S40 - S42
  • [7] Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows
    Bernabucci, U
    Ronchi, B
    Lacetera, N
    Nardone, A
    [J]. JOURNAL OF DAIRY SCIENCE, 2005, 88 (06) : 2017 - 2026
  • [8] Oxidative stress
    Burton, Graham J.
    Jauniaux, Eric
    [J]. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2011, 25 (03) : 287 - 299
  • [9] STIMULATION OF PROGESTERONE SECRETION IN DISPERSED CELLS OF RAT CORPORA-LUTEA BY ANTIOXIDANTS
    CARLSON, JC
    SAWADA, M
    BOONE, DL
    STAUFFER, JM
    [J]. STEROIDS, 1995, 60 (03) : 272 - 276
  • [10] Effects of feeding a source of omega-3 fatty acid during the early postpartum period on the endocannabinoid system in the bovine endometrium
    Dirandeh, E.
    Ghaffari, J.
    [J]. THERIOGENOLOGY, 2018, 121 : 141 - 146