Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion

被引：52

作者：

Formento Navarini, Andreia Lilian ^{[1
]}

Chiaradia, Louise Domeneghini ^{[2
]}

Mascarello, Alessandra ^{[2
]}

Fritzen, Marcio ^{[1
]}

Nunes, Ricardo Jose ^{[2
]}

Yunes, Rosendo Augusto ^{[2
]}

Creczynski-Pasa, Tania Beatriz ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Saude, Dept Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 04期

关键词：

Hydroxychalcones; Melanoma; Antitumoral; Apoptosis; GSH; ATP; MALIGNANT-MELANOMA; 4A5; CELLS; G2; CHALCONES; CANCER; GROWTH; AGENTS; ISOLIQUIRITIGENIN; HETEROGENEITY; CYTOTOXICITY;

D O I：

10.1016/j.ejmech.2008.09.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Searching for leading compounds of new drugs for cancer therapy, we studied the toxicity of 13 hydroxychalcones never tested before toward melanoma cell line (B16-F10). The compounds were obtained by aldolic condensation between aldehydes and hydroxylated acetophenones, in alkaline conditions. Three of them showed cytotoxicity to the cell line. Two of them induced mitochondrial GSH and ATP depletion and promoted cell death through apoptosis in melanoma cells. One of the compounds induced cell death through necrosis but did not significantly decrease the intracellular mitochondrial GSH and ATP levels in melanoma cells. The results suggest that the predominant factor for the activity is the molecule shape, and secondarily the number of hydroxyl groups. (c) 2008 Published by Elsevier Masson SAS.

引用

页码：1630 / 1637

页数：8

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