Molecular and biochemical basis for the platelet dysfunction in myeloproliferative disorders

被引：6

作者：

Rao, AK ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Philadelphia, PA 19140 USA

来源：

SEMINARS IN HEMATOLOGY | 2004年 / 41卷 / 02期

关键词：

D O I：

10.1053/j.seminhematol.2004.02.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A large number of platelet abnormalities have been described in patients with myeloprolIferative disorders (MPDs). Platelet abnormalities include defects in receptor expression on the platelet surface, platelet-platelet interactions, and platelet activation mechanisms. These platelet defects are demonstrable even in patients who are asymptomatic. Both hemorrhagic and thrombotic events occur in MPD patients. The mechanisms that underlie the platelet dysfunction in patients with MPDs are examined. © 2004 Elsevier Inc. All rights reserved.

引用

页码：6 / 9

页数：4

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