Synthesis, structural investigations, DFT studies, and neurotrophic activity of zinc complex with a multidentate ligand

被引：6
作者：
Azam, Mohammad [1 ]
Wabaidur, Saikh Mohammad [1 ]
Al-Resayes, Saud I. [1 ]
Alam, Mahboob [2 ]
Haque, Md. Nazmul [3 ,4 ]
Moon, Il Soo [4 ]
Rajendra [5 ]
机构：
[1] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
[2] Dongguk Univ, Div Chem & Biotechnol, 123 Dongdae Ro, Gyeongju, South Korea
[3] Patuakali Sci & Technol Univ, Dept Fisheries Biol & Genet, Patuakhali 8602, Bangladesh
[4] Dongguk Univ, Sch Med, Dept Anat, Gyeongju 38066, South Korea
[5] Banasthali Vidyapith, Dept Chem, Banasthali 304022, Rajasthan, India
来源：
MONATSHEFTE FUR CHEMIE | 2020年 / 151卷 / 11期
关键词：
Zinc(II) complex; DFT studies; Neurotrophic activity; SCHIFF-BASE LIGANDS; SOD-LIKE ACTIVITY; CRYSTAL-STRUCTURES; COPPER(II) COMPLEXES; LANTHANIDE COMPLEXES; OXIDATIVE STRESS; METAL-COMPLEXES; COORDINATION; NEUROGENESIS; NI(II);
D O I：
10.1007/s00706-020-02696-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel zinc complex derived from a multidentate ligand, nitrilotris(ethane-2,1-diyl)tris(azanylylidene)tris(methanylylidene)tris(2-methoxyphenol), was designed and structurally investigated by elemental analyses, IR, NMR, ESI-MS, and UV-Vis studies. The density functional theory was also recorded to investigate the additional insights into the structural and electronic properties of the ligand and its complex. Both the ligand and its complex showed significant neurite outgrowth and viability in brain neuron at lower concentration when investigated for neurological properties. Thus, it can be suggested that the ligand and its complex may play a potential role in brain development, functioning as well as in the treatment of neurological disorders.
引用
收藏
页码：1715 / 1726
页数：12
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