Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity

被引：23

作者：

Baran, Alper ^{[1
]}

Sulukan, Ekrem ^{[2
,3
]}

Turkoglu, Medine ^{[3
,4
]}

Ghosigharehagaji, Atena ^{[3
]}

Yildirim, Serkan ^{[5
]}

Kankaynar, Meryem ^{[3
,4
]}

Bolat, Ismail ^{[5
]}

Kaya, Mukerrem ^{[6
]}

Topal, Ahmet ^{[7
]}

Ceyhun, Saltuk Bugrahan ^{[3
,4
]}

机构：

[1] Ataturk Univ, Erzurum Vocat Sch, Dept Food Qual & Anal, Erzurum, Turkey

[2] Ataturk Univ, Fac Fisheries, Dept Aquaculture, TR-25240 Erzurum, Turkey

[3] Ataturk Univ, Fac Fisheries, Aquat Biotechnol Lab, Erzurum, Turkey

[4] Ataturk Univ, Grad Sch Nat & Appl Sci, Dept Nanosci, Erzurum, Turkey

[5] Ataturk Univ, Fac Vet, Dept Pathol, Erzurum, Turkey

[6] Ataturk Univ, Fac Agr, Dept Food Engn, Erzurum, Turkey

[7] Ataturk Univ, Fac Fisheries, Dept Basic Sci, TR-25240 Erzurum, Turkey

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 163卷

关键词：

Lipid metabolism; Zebrafish; Toxicity; Obesity; Oxidative stress; BLOOD-FLOW; METABOLISM; TOXICITY; INFLAMMATION; IMPACT;

D O I：

10.1016/j.ijbiomac.2020.09.169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The toxicity of sodiumcarboxymethyl cellulose (CMC), which has GRAS status and has been determined as "ADI non specified", was re-evaluated with a new modelling and molecular-based data. For this purpose, CMC, a food additive, was injected to the yolk sac (food) of the zebrafish embryo by the microinjection method at the 4th hour of fertilization at different concentrations. As a result, it was found that CMC showed no toxic effects within the framework of the parameters studied. But, we determined increasing lipid accumulation in zebrafish embryos exposed to CMC in a dose-dependent manner. To elucidate the mechanism underlying this lipid accumulation, the expression levels of genes related to obesity-linked lipid metabolism were examined. Our findings show that while CMC does not cause a toxic effect in zebrafish embryos, it can lead important effects on lipid metabolism by causing changes in the expression of some genes associated with obesity. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：2465 / 2473

页数：9

共 39 条

[1] SUBCHRONIC ORAL TOXICITY STUDY WITH REGULAR AND ENZYMATICALLY DEPOLYMERIZED SODIUM CARBOXYMETHYLCELLULOSE IN RATS
BAR, A
TIL, HP
TIMONEN, M
[J]. FOOD AND CHEMICAL TOXICOLOGY, 1995, 33 (11) : 909 - 917
[2] Bringman G., 1977, Z WASSER ABWASSER FO, V10, P87
[3] The central melanocortin system regulates food intake in goldfish
Cerdá-Reverter, JM
Schiöth, HB
Peter, RE
[J]. REGULATORY PEPTIDES, 2003, 115 (02) : 101 - 113
[4] Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain
Chakravarty, B
Gu, ZW
Chirala, SS
Wakil, SJ
Quiocho, FA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) : 15567 - 15572
[5] Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Chassaing, Benoit
Koren, Omry
Goodrich, Julia K.
Poole, Angela C.
Srinivasan, Shanthi
Ley, Ruth E.
Gewirtz, Andrew T.
[J]. NATURE, 2015, 519 (7541) : 92 - U192
[6] Desesso J. M., 1995, Teratology, V51, P167
[7] Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei
Esteves, Adriana
Knoll-Gellida, Anja
Canclini, Lucia
Silvarrey, Maria Cecilia
Andre, Michele
Babin, Patrick J.
[J]. JOURNAL OF LIPID RESEARCH, 2016, 57 (02) : 219 - 232
[8] Obese zebrafish: A small fish for a major human health condition
Faillaci, Francesca
Milosa, Fabiola
Critelli, Rosina Maria
Turola, Elena
Schepis, Filippo
Villa, Erica
[J]. ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2018, 1 (04) : 255 - 265
[9] FDA, 2015, GRAS SUBST SCOGS DAT
[10] FRITZ H, 1981, ARZNEIMITTEL-FORSCH, V31-1, P813

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