Structure of onchidione, a bis-γ-pyrone polypropionate from a marine pulmonate mollusk

被引:27
作者
Carbone, Marianna [1 ]
Gavagnin, Margherita [1 ]
Mattia, Carlo A. [2 ]
Lotti, Cinzia [1 ]
Castelluccio, Francesco [1 ]
Pagano, Bruno [2 ]
Mollo, Ernesto [1 ]
Guo, Yue-Wei [3 ]
Cimino, Guido [1 ]
机构
[1] CNR, Ist Chim Biomol, I-80078 Naples, Italy
[2] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy
[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
关键词
Marine natural products; Polypropionates; Pyrones; Pulmonata; X-ray analysis; CONTAINING NATURAL-PRODUCTS; ILIKONAPYRONE; METABOLITES;
D O I
10.1016/j.tet.2009.03.052
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The chemical investigation of the marine pulmonate Onchidium sp. and of its defensive mucous secretion led us to the isolation of a novel polypropionate, onchidione (4), containing two gamma-pyrone rings. The structure of 4 was elucidated by spectroscopic methods, mainly NMR techniques, and secured by X-ray analysis on a single crystal. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4404 / 4409
页数:6
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