Sensor-less checkpoint activation?

被引：13

作者：

Michelson, R ^{[1
]}

Weinert, T ^{[1
]}

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 07期

关键词：

D O I：

10.1038/15614

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA damage activates a set of proteins whose job is to delay the cell cycle until the damage is repaired. This process was thought to involve the detection of damage by sensor proteins, which transmit a signal to a key protein kinase and thence to downstream targets. Unexpectedly, damage can also activate the kinase directly.

引用

页码：E177 / E179

页数：3

共 17 条

[1] Requirement for p53 and p21 to sustain G2 arrest after DNA damage
Bunz, F
Dutriaux, A
Lengauer, C
Waldman, T
Zhou, S
Brown, JP
Sedivy, JM
Kinzler, KW
Vogelstein, B
[J]. SCIENCE, 1998, 282 (5393) : 1497 - 1501
[2] Control of cell cycle arrest by the Mec1(sc)/Rad3(sp) DNA structure checkpoint pathway
Carr, AM
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (01) : 93 - 98
[3] AKAPs: from structure to function
Colledge, M
Scott, JD
[J]. TRENDS IN CELL BIOLOGY, 1999, 9 (06) : 216 - 221
[4] A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
Edwards, RJ
Bentley, NJ
Carr, AM
[J]. NATURE CELL BIOLOGY, 1999, 1 (07) : 393 - 398
[5] Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity
Gately, DP
Hittle, JC
Chan, GKT
Yen, TJ
[J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (09) : 2361 - 2374
[6] GRUSHCOW J, IN PRESS GENETICS
[7] Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
Martin, SG
Laroche, T
Suka, N
Grunstein, M
Gasser, SM
[J]. CELL, 1999, 97 (05) : 621 - 633
[8] Matsuura A, 1999, GENETICS, V152, P1501
[9] MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
Mills, KD
Sinclair, DA
Guarente, L
[J]. CELL, 1999, 97 (05) : 609 - 620
[10] Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
Paciotti, V
Lucchini, G
Plevani, P
Longhese, MP
[J]. EMBO JOURNAL, 1998, 17 (14) : 4199 - 4209

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