Behavioral effects of transcranial Direct Current Stimulation (tDCS) induced dorsolateral prefrontal cortex plasticity in alcohol dependence

被引：146

作者：

da Silva, Morgana Croce ^{[1
,2
]}

Conti, Catarine Lima ^{[1
,2
]}

Klauss, Jaisa ^{[1
,2
]}

Alves, Luana Gaburro ^{[1
,2
]}

do Nascimento Cavalcante, Henrique Mineiro ^{[1
,2
]}

Fregni, Felipe ^{[3
,4
]}

Nitsche, Michael A. ^{[5
]}

Nakamura-Palacios, Ester Miyuki ^{[1
,2
]}

机构：

[1] Univ Fed Espirito Santo, Program Postgrad Physiol Sci, Lab Cognit Sci & Neuropsychopharmacol, BR-29047105 Vitoria, ES, Brazil

[2] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Lab Neuromodulat, Boston, MA USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat,Med Sc, Boston, MA 02215 USA

[5] Univ Gottingen, Dept Clin Neurophysiol, Univ Med Ctr, Lab Neuroplast, D-37073 Gottingen, Germany

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 2013年 / 107卷 / 06期

关键词：

Anodal tDCS; Alcoholics; Prefrontal cortex; EEG; Event-related potential; LORETA; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; FRONTAL ASSESSMENT BATTERY; IMPROVING WORKING-MEMORY; HUMAN MOTOR CORTEX; DOUBLE-BLIND; CORTICAL EXCITABILITY; DC STIMULATION; NEURAL RESPONSE; MODULATION; ADDICTION;

D O I：

10.1016/j.jphysparis.2013.07.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transcranial Direct Current Stimulation (tDCS) has been shown to reduce acute substance craving in drug addicts, and improve cognition in neuropsychiatric patients. Here we aimed to explore further tDCS induced behavioral and neurophysiological modulation including assessment of relapse rate over a prolonged time course in alcoholism. We examined the effects of repeated anodal tDCS (2 mA, 35 cm(2), 20 min) over the left dorsolateral prefrontal cortex (DLPFC) on relapse to the use of alcohol in alcoholics from outpatient services, who received additional routine clinical treatment. Furthermore, event related potentials (ERPs), cognitive and frontal executive processes, craving, depressive and anxiety symptoms were obtained before and after treatment. From thirteen alcoholic subjects, seven were randomized to sham-tDCS and six to real tDCS treatment (once a week for five consecutive weeks). Depressive symptoms and craving were reduced to a larger extent in the tDCS group compared to the sham group (p = 0.005 and p = 0.015, respectively). On the other hand, active tDCS was able to block the increase in neural activation triggered by alcohol related and neutral cues in prefrontal cortex (PFC) as indexed by ERP as seen in the sham-tDCS group. Finally, there was a trend for increased change in executive function in the tDCS group compared to the sham-tDCS group (p = 0.082), and, similarly, a trend for more relapses in the tDCS group compared to sham tDCS (four alcoholic subjects (66.7%) vs. one (14.3%), p = 0.053). These results confirm the previous findings of tDCS effects on craving in alcoholism and also extend these findings as we showed also tDCS-related mood improvement. However, potential increase in relapse is possible; thus the clinical value of an increase in craving and improvement in depression and executive function needs to be carefully assessed in further studies; including investigation of optimal parameters of stimulation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：493 / 502

页数：10

共 92 条

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