Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

被引：93

作者：

Ansari, Shamshul ^{[1
]}

Yamaoka, Yoshio ^{[2
,3
,4
,5
]}

机构：

[1] Chitwan Med Coll, Dept Microbiol, Bharatpur 44200, Nepal

[2] Oita Univ, Dept Environm & Prevent Med, Fac Med, Yufu, Oita 8795593, Japan

[3] Global Oita Med Adv Res Ctr Hlth GO MARCH, Yufu, Oita 8795593, Japan

[4] Baylor Coll Med, Gastroenterol & Hepatol Sect, Dept Med, Houston, TX 77030 USA

[5] Univ Malaysia Sabah, Borneo Med & Hlth Res Ctr, Kota Kinabalu 88400, Sabah, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 19期

关键词：

H; pylori; virulence factor; cag pathogenicity island; CagA; gastric cancer; EPITHELIAL-MESENCHYMAL TRANSITION; VARIANT; 9; EXPRESSION; IV SECRETION SYSTEM; ABL KINASES; CANCER; CAGA; ISLAND; PROTEIN; CELLS; MECHANISMS;

D O I：

10.3390/ijms21197430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of the world's population, leading to the development of severe complications such as peptic ulcer diseases, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Several virulence factors, including cytotoxin-associated gene A (CagA), which is translocated into the gastric epithelium via the type 4 secretory system (T4SS), have been indicated to play a vital role in disease development. Although infection with strains harboring the East Asian type of CagA possessing the EPIYA-A, -B, and -D sequences has been found to potentiate cell proliferation and disease pathogenicity, the exact mechanism of CagA involvement in disease severity still remains to be elucidated. Therefore, we discuss the possible role of CagA in gastric pathogenicity.

引用

页码：1 / 16

页数：16

共 128 条

[1] Analyses of the cag pathogenicity island of Helicobacter pylori [J].

Akopyants, NS ;

Clifton, SW ;

Kersulyte, D ;

Crabtree, JE ;

Youree, BE ;

Reece, CA ;

Bukanov, NO ;

Drazek, ES ;

Roe, BA ;

Berg, DE .

MOLECULAR MICROBIOLOGY, 1998, 28 (01) :37-53

[2] Pathobiology of Helicobacter pylori-Induced Gastric Cancer [J].

Amieva, Manuel ;

Peek, Richard M., Jr. .

GASTROENTEROLOGY, 2016, 150 (01) :64-78

[3] Role of vacuolating cytotoxin A inHelicobacter pyloriinfection and its impact on gastric pathogenesis [J].

Ansari, Shamshul ;

Yamaoka, Yoshio .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2020, 18 (10) :987-996

[4] PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives [J].

Asati, Vivek ;

Mahapatra, Debarshi Kar ;

Bharti, Sanjay Kumar .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 109 :314-341

[5] Inhibition of heat shock protein expression by Helicobacter pylori [J].

Axsen, Wendy S. ;

Styer, Cathy M. ;

Solnick, Jay V. .

MICROBIAL PATHOGENESIS, 2009, 47 (04) :231-236

[6] The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling [J].

Backert, Steffen ;

Haas, Rainer ;

Gerhard, Markus ;

Naumann, Michael .

TYPE IV SECRETION IN GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA, 2018, 413 :187-220

[7] Pathogenesis of Helicobacter pylori infection [J].

Backert, Steffen ;

Neddermann, Matthias ;

Maubach, Gunter ;

Naumann, Michael .

HELICOBACTER, 2016, 21 :19-25

[8]

Backert S, 2015, FUTURE MICROBIOL, V10, P955, DOI [10.2217/FMB.15.32, 10.2217/fmb.15.32]

[9] Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells [J].

Bagnoli, F ;

Buti, L ;

Tompkins, L ;

Covacci, A ;

Amieva, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (45) :16339-16344

[10] CagY Is an Immune-Sensitive Regulator of the Helicobacter pylori Type IV Secretion System [J].

Barrozo, Roberto M. ;

Hansen, Lori M. ;

Lam, Anna M. ;

Skoog, Emma C. ;

Martin, Miriam E. ;

Cai, Lucy P. ;

Lin, Yong ;

Latoscha, Andreas ;

Suerbaum, Sebastian ;

Canfield, Don R. ;

Solnick, Jay V. .

GASTROENTEROLOGY, 2016, 151 (06) :1164-+

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