RNA-mediated gene silencing in non-pathogenic and pathogenic fungi

被引：18
作者：
De Backer, MD
Raponi, M
Arndt, GM
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, Dept GI Emerging Dis, B-2340 Beerse, Belgium
[2] Ortho Clin Diagnost, Mol Diagnost, San Diego, CA 92121 USA
[3] Johnson & Johnson Res, Sydney, NSW 1430, Australia
来源：
CURRENT OPINION IN MICROBIOLOGY | 2002年 / 5卷 / 03期
关键词：
D O I：
10.1016/S1369-5274(02)00319-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Many fungal genomes have now been sequenced and thousands of genes are being discovered. Gene disruption or inactivation technology offers an important tool not only for elucidating the function of the many unknown genes but also for the identification of genes essential for fungal growth and pathogenesis. A variety of gene-silencing methods that inhibit genes at the post-transcriptional level are now being used in both non-pathogenic and human pathogenic fungi. We focus on the recent advances in RNA-mediated gene silencing technologies and their potential for functional genomics studies in fungi.
引用
收藏
页码：323 / 329
页数：7
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