A One-Pot, Four-Component Synthesis of N-Substituted 2,4-Diarylimidazoles

被引：41

作者：

Adib, Mehdi ^{[1
]}

Ansari, Samira ^{[1
]}

Feizi, Shahzad ^{[1
]}

Damavandi, Jafar Asgarian ^{[2
]}

Mirzaei, Peiman ^{[3
]}

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Teacher Training Univ, Fac Chem, Tehran 15614, Iran

[3] Shahid Beheshti Univ Med Sci, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2009年 / 20期

关键词：

1,2,4-trisubstituted 1H-imidazoles; aldehydes; primary amines; four-component reactions; cyclizations; heterocycles; TETRASUBSTITUTED IMIDAZOLES; 3-COMPONENT SYNTHESIS; EFFICIENT; CHEMISTRY; ANALOGS; AMINO;

D O I：

10.1055/s-0029-1218381

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, four-component synthesis of 1,2,4-trisubstituted 1H-imidazoles is described. Heating a mixture of a 2-bromoacetophenone, an aldehyde, a primary amine, and ammonium acetate under solvent-free conditions affords functionalized imidazoles in good to excellent yields.

引用

页码：3263 / 3266

页数：4

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