Development of a library of 6-arylcoumarins as candidate fluorescent sensors

被引：57

作者：

Hirano, Tomoya ^{[1
]}

Hiromoto, Kenichi ^{[1
]}

Kagechika, Hiroyuki ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Sch Biomed Sci, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 07期

关键词：

D O I：

10.1021/ol070142z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bromocoumarin scaffold (1) was reacted with various boronic acid derivatives (2a-l) to afford a library of 6-arylcoumarins (3a-l). This library was found to contain candidate fluorescent sensors for peptidase activity and for nitric oxide.

引用

页码：1315 / 1318

页数：4

共 25 条

[1]

[Anonymous], 2006, PRINCIPLES FLUORESCE

[2] Matrix screening of substituted N-aryl-1,8-naphthalimides reveals new dual fluorescent dyes and unusually bright pyridine derivatives [J].

Cao, H ;

Chang, V ;

Hernandez, R ;

Heagy, MD .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (13) :4929-4934

[3] Synthesis and fluorescence properties of substituted 7-aminocoumarin-3-carboxylate derivatives [J].

Corrie, JET ;

Munasinghe, VRN ;

Rettig, W .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (06) :1447-1455

[4] Effect of protic solvents on twisted intramolecular charge transfer state formation in coumarin-152 and coumarin-481 dyes [J].

Dahiya, P ;

Kumbhakar, M ;

Mukherjee, T ;

Pal, H .

CHEMICAL PHYSICS LETTERS, 2005, 414 (1-3) :148-154

[5] Signaling recognition events with fluorescent sensors and switches [J].

de Silva, AP ;

Gunaratne, HQN ;

Gunnlaugsson, T ;

Huxley, AJM ;

McCoy, CP ;

Rademacher, JT ;

Rice, TE .

CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566

[6] Combinatorial discovery of fluorophores and fluorescent probes [J].

Finney, NS .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (03) :238-245

[7] Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe [J].

Gabe, Y ;

Urano, Y ;

Kikuchi, K ;

Kojima, H ;

Nagano, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) :3357-3367

[8] MEDIUM EFFECTS ON FLUORESCENCE QUANTUM YIELDS AND LIFETIMES FOR COUMARIN LASER-DYES [J].

JONES, G ;

JACKSON, WR ;

HALPERN, AM .

CHEMICAL PHYSICS LETTERS, 1980, 72 (02) :391-395

[9] PREPARATION, PHOTOCHEMISTRY, AND ELECTRONIC-STRUCTURES OF COUMARIN LASER-DYE COMPLEXES OF CYCLOPENTADIENYLRUTHENIUM(II) [J].

KOEFOD, RS ;

MANN, KR .

INORGANIC CHEMISTRY, 1989, 28 (12) :2285-2290

[10] Detection and imaging of nitric oxide with novel fluorescent indicators: Diaminofluoresceins [J].

Kojima, H ;

Nakatsubo, N ;

Kikuchi, K ;

Kawahara, S ;

Kirino, Y ;

Nagoshi, H ;

Hirata, Y ;

Nagano, T .

ANALYTICAL CHEMISTRY, 1998, 70 (13) :2446-2453

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