Evaluation of a modification of the UPOINT clinical phenotype system for the chronic pelvic pain syndrome

Objective. To evaluate the recently presented six-domain UPOINT phenotype system for the chronic abacterial prostatitis/chronic pelvic pain syndrome (CPPS) and to correlate it with clinically relevant parameters such as ejaculatory pain, pain localization, erectile dysfunction, cold sensitivity and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Material and methods. Fifty men with CPPS were classified in each of the six UPOINT domains. A CPPS focused history was obtained and the men were asked to complete the NIH-CPSI, the International Index of Erectile Function (IIEF-5) and the Coping Strategies Questionnaire (CSQ). Results. The mean age was 46 years (range 26-71 years). The percentage positive for each domain was 26 (52%) for urinary, 18 (36%) for psychosocial, 19 (38%) for organ specific, 19 (38%) for infection, 18 (36%) for neurological/systemic and 16 (32%) for pelvic muscle tenderness. Mean NIH-CPSI was 23 +/- 7. The number of positive domains and the NIH-CPSI [correlation coefficient (r)=0.478, p=0.002] and its quality of life section (r=0.432, p=0.003) were linked; there was, however, no correlation between the number of positive domains and IIEF-5, ejaculatory pain, painful micturition, cold sensitivity or pain localization (except for scrotal pain). The link between catastrophizing and NIH-CPSI was marked (r=0.61, p<0.001). Conclusions. The correlation between the UPOINT score and NIH-CPSI was verified. A weak or lacking correlation with the studied clinical parameters suggests that further development is required before UPOINT can be considered an optimal phenotyping instrument.