BRCA2 Shining light on the regulation of DNA-binding selectivity by RAD51

被引:10
作者
Carreira, Aura
Kowalczykowski, Stephen C. [1 ]
机构
[1] Univ Calif Davis, Dept Microbiol, Davis, CA 95616 USA
关键词
SUSCEPTIBILITY GENE BRCA2; STRAND EXCHANGE; OVARIAN-CANCER; BREAST; REPEATS; PROTEIN; REPAIR; RECOMBINATION; COMPLEX; FILAMENTS;
D O I
10.4161/cc.8.21.9748
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:3445 / 3447
页数:3
相关论文
共 25 条
[1]  
Bianco P.R., 1998, FRONT BIOSCI-LANDMRK, V3, P570, DOI [10.2741/A304, DOI 10.2741/A304]
[2]   The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51 [J].
Carreira, Aura ;
Hilario, Jovencio ;
Amitani, Ichiro ;
Baskin, Ronald J. ;
Shivji, Mahmud K. K. ;
Venkitaraman, Ashok R. ;
Kowalczykowski, Stephen C. .
CELL, 2009, 136 (06) :1032-1043
[3]   Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G2/M checkpoint control [J].
Chen, CF ;
Chen, PL ;
Zhong, Q ;
Sharp, ZD ;
Lee, WH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32931-32935
[4]   Role of BRCA2 in control of the RAD51 recombination and DNA repair protein [J].
Davies, AA ;
Masson, JY ;
Mcllwraith, MJ ;
Stasiak, AZ ;
Stasiak, A ;
Venkitaraman, AR ;
West, SC .
MOLECULAR CELL, 2001, 7 (02) :273-282
[5]   CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair [J].
Esashi, F ;
Christ, N ;
Gannon, J ;
Liu, YL ;
Hunt, T ;
Jasin, M ;
West, SC .
NATURE, 2005, 434 (7033) :598-604
[6]   BRCA2 BRC motifs bind RAD51-DNA filaments [J].
Galkin, VE ;
Esashi, F ;
Yu, X ;
Yang, SX ;
West, SC ;
Egelman, EH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) :8537-8542
[7]   Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules [J].
Hilario, Jovencio ;
Amitani, Ichiro ;
Baskin, Ronald J. ;
Kowalczykowski, Stephen C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (02) :361-368
[8]   EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer [J].
Hughes-Davies, L ;
Huntsman, D ;
Ruas, M ;
Fuks, F ;
Bye, J ;
Chin, SF ;
Milner, J ;
Brown, LA ;
Hsu, F ;
Gilks, B ;
Nielsen, T ;
Schulzer, M ;
Chia, S ;
Ragaz, J ;
Cahn, A ;
Linger, L ;
Ozdag, H ;
Cattaneo, E ;
Jordanova, ES ;
Schuuring, E ;
Yu, DS ;
Venkitaraman, A ;
Ponder, B ;
Doherty, A ;
Aparicio, S ;
Bentley, D ;
Theillet, C ;
Ponting, CP ;
Caldas, C ;
Kouzarides, T .
CELL, 2003, 115 (05) :523-535
[9]   Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer [J].
Lo, T ;
Pellegrini, L ;
Venkitaraman, AR ;
Blundell, TL .
DNA REPAIR, 2003, 2 (09) :1015-1028
[10]  
Marston NJ, 1999, MOL CELL BIOL, V19, P4633