Viewing molecular mechanisms of ageing through a lens

被引：106

作者：

Harding, JJ ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Lab Ophthalmol, Oxford OX2 6AW, England

来源：

AGEING RESEARCH REVIEWS | 2002年 / 1卷 / 03期

关键词：

ageing; cataract; conformational disease; alpha-crystallin; post-translational modification of proteins; unfolding;

D O I：

10.1016/S1568-1637(02)00012-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many late-life diseases are conformational diseases in tissues where there are unfolded or mis-folded proteins which can form aggregates. These diseases have other common features in their aetiology. Cataract is one such disease and post-translational modifications of proteins in the lens during cataract formation are described as a possible guide to the changes in other age-related conditions. Delineation of common pathways in these diseases could lead to common treatment regimes, and in this respect, there are promising results for aspirin-like drugs in Alzheimer's disease, cataract, myocardial infarction, stroke and various cancers. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：465 / 479

页数：15

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