Chromatography-free synthesis of 1,2,4-oxadiazoles using ROMPGEL-supported acylating reagents

被引：22

作者：

Barrett, AGM ^{[1
]}

Cramp, SM

Roberts, RS

Zécri, FJ

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] Aventis CorpSci, Ongar CM5 0HW, Essex, England

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2000年 / 3卷 / 02期

关键词：

D O I：

10.2174/1386207003331733

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

1,2,4-Oxadiazoles were synthesized in solution from aromatic amidoximes and acylating agents supported on a ring opening metathesis polymer (ROMPGEL) backbone. High yields and purities of the 1,2,4-oxadiazoles were obtained with minimal purification.

引用

页码：131 / 138

页数：8

共 30 条

[1] A ROMPGEL-supported N-hydroxysuccinimide:: A host of acylations with minimal purification [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 2000, 2 (03) :261-264

[2] Horner-Emmons synthesis with minimal purification using ROMPGEL: A novel high-loading matrix for supported reagents [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 1999, 1 (04) :579-582

[3] ROMP-spheres: A novel high-loading polymer support using cross metathesis between vinyl polystyrene and norbornene derivatives [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS .

ORGANIC LETTERS, 1999, 1 (07) :1083-1086

[4] Rapid entry into mono-, bi-, and tricyclic β-lactam arrays via alkene metathesis [J].

Barrett, AGM ;

Baugh, SPD ;

Braddock, DC ;

Flack, K ;

Gibson, VC ;

Giles, MR ;

Marshall, EL ;

Procopiou, PA ;

White, AJP ;

Williams, DJ .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (22) :7893-7907

[5] SYNTHESIS OF STAR BLOCK COPOLYMERS BY CONTROLLED RING-OPENING METATHESIS POLYMERIZATION [J].

BAZAN, GC ;

SCHROCK, RR .

MACROMOLECULES, 1991, 24 (04) :817-823

[6] Solid-supported reagent strategies for rapid purification of combinatorial synthesis products [J].

Booth, RJ ;

Hodges, JC .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (01) :18-26

[7] Access to well-defined heterogeneous catalytic systems via ring-opening metathesis polymerization (ROMP): Applications in palladium(II)-mediated coupling reactions [J].

Buchmeiser, MR ;

Wurst, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (48) :11101-11107

[8] Ring-opening-metathesis polymerization for the preparation of carboxylic-acid-functionalized, high-capacity polymers for use in separation techniques [J].

Buchmeiser, MR ;

Atzl, N ;

Bonn, GK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (39) :9166-9174

[9] IMPROVED FISCHER INDOLE REACTION FOR THE PREPARATION OF N,N-DIMETHYLTRYPTAMINES - SYNTHESIS OF L-695,894, A POTENT 5-HT1D RECEPTOR AGONIST [J].

CHEN, CY ;

SENANAYAKE, CH ;

BILL, TJ ;

LARSEN, RD ;

VERHOEVEN, TR ;

REIDER, PJ .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (13) :3738-3741

[10] A SIMPLIFIED PROCEDURE FOR PREPARING 3,5-DISUBSTITUTED-1,2,4-OXADIAZOLES BY REACTION OF AMIDOXIMES WITH ACYL CHLORIDES IN PYRIDINE SOLUTION [J].

CHIOU, S ;

SHINE, HJ .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (01) :125-128

← 1 2 3 →