Chromatography-free synthesis of 1,2,4-oxadiazoles using ROMPGEL-supported acylating reagents

被引:22
作者
Barrett, AGM [1 ]
Cramp, SM
Roberts, RS
Zécri, FJ
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England
[2] Aventis CorpSci, Ongar CM5 0HW, Essex, England
关键词
D O I
10.2174/1386207003331733
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
1,2,4-Oxadiazoles were synthesized in solution from aromatic amidoximes and acylating agents supported on a ring opening metathesis polymer (ROMPGEL) backbone. High yields and purities of the 1,2,4-oxadiazoles were obtained with minimal purification.
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页码:131 / 138
页数:8
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