Live or Let Die: CCM2 Provides the Link

被引：2

作者：

Gruber-Olipitz, Mariella ^{[1
,2
]}

Segal, Rosalind A. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Canc Biol & Pediat Oncol, Boston, MA 02115 USA

来源：

NEURON | 2009年 / 63卷 / 05期

关键词：

CEREBRAL CAVERNOUS MALFORMATIONS; TRK NEUROTROPHIN RECEPTORS; MEDULLOBLASTOMA; PATHOGENESIS;

D O I：

10.1016/j.neuron.2009.08.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TrkA receptors are well known for promoting neuronal cell survival. However, in some neuroblastic tumors, TrkA activation can instead induce apoptosis. In this issue of Neuron, Harel et al. identify CCM2 as a mediator of TrkA-dependent cell death, suggesting that CCM2 is a distinctive type of tumor suppressor that modulates tyrosine kinase signaling.

引用

页码：559 / 560

页数：2

共 12 条

[1] Trk Receptor Expression and Inhibition in Neuroblastomas [J].

Brodeur, Garrett M. ;

Minturn, Jane E. ;

Ho, Ruth ;

Simpson, Anisha M. ;

Iyer, Radhika ;

Varela, Carly R. ;

Light, Jennifer E. ;

Kolla, Venkatadri ;

Evans, Audrey E. .

CLINICAL CANCER RESEARCH, 2009, 15 (10) :3244-3250

[2] Neuroblastoma: Biological insights into a clinical enigma [J].

Brodeur, GM .

NATURE REVIEWS CANCER, 2003, 3 (03) :203-216

[3] Apoptotic Functions of PDCD10/CCM3, the Gene Mutated in Cerebral Cavernous Malformation 3 [J].

Chen, Leiling ;

Tanriover, Gamze ;

Yano, Hiroko ;

Friedlander, Robert ;

Louvi, Angeliki ;

Gunel, Murat .

STROKE, 2009, 40 (04) :1474-1481

[4] A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors [J].

Chen, ZY ;

Ieraci, A ;

Tanowitz, M ;

Lee, FS .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (12) :5761-5772

[5] Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective [J].

de Bont, Judith M. ;

Packer, Roger J. ;

Michiels, Erna M. ;

den Boer, Monique L. ;

Pieters, Rob .

NEURO-ONCOLOGY, 2008, 10 (06) :1040-1060

[6] CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase [J].

Harel, Liraz ;

Costa, Barbara ;

Tcherpakov, Marianna ;

Zapatka, Marc ;

Oberthuer, Andre ;

Hansford, Loen M. ;

Vojvodic, Milijana ;

Levy, Zehava ;

Chen, Zhe-Yu ;

Lee, Francis S. ;

Avigad, Smadar ;

Yaniv, Isaac ;

Shi, Leming ;

Eils, Roland ;

Fischer, Matthias ;

Brors, Benedikt ;

Kaplan, David R. ;

Fainzilber, Mike .

NEURON, 2009, 63 (05) :585-591

[7]

Kim JYH, 1999, CANCER RES, V59, P711

[8] Neurotrophins in cerebellar granule cell development and medulloblastoma [J].

Pomeroy, SL ;

Sutton, ME ;

Goumnerova, LC ;

Segal, RA .

JOURNAL OF NEURO-ONCOLOGY, 1997, 35 (03) :347-352

[9] Neuratrophin-regulated signalling pathways [J].

Reichardt, Louis F. .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 361 (1473) :1545-1564

[10] CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations [J].

Voss, Katrin ;

Stahl, Sonja ;

Schleider, Elisa ;

Ullrich, Sybille ;

Nickel, Joachim ;

Mueller, Thomas D. ;

Felbor, Ute .

NEUROGENETICS, 2007, 8 (04) :249-256

← 1 2 →