Combined effects of Diospyros lotus leaf and grape stalk extract in high-fat-diet-induced obesity in mice

被引：13

作者：

Che, Denis Nchang ^{[1
,2
]}

Kang, Hyun Ju ^{[3
]}

Cho, Byoung Ok ^{[1
,3
]}

Shin, Jae Young ^{[1
]}

Jang, Seon Il ^{[1
,3
]}

机构：

[1] Jeonju Univ, Dept Hlth Management, 303 Cheonjam Ro, Jeonju 55069, Jeollabuk Do, South Korea

[2] Chonbuk Natl Univ, Dept Food Sci & Technol, Jeonju 54896, Jeollabuk Do, South Korea

[3] Ato Q&A Co LTD, Res Inst, Jeonju 54840, Jeollabuk Do, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2019年 / 28卷 / 04期

关键词：

Combined effect; Diospyros lotus leaf; Muscat Bailey A grape stalk; Obesity; INDUCED SKIN DAMAGE; INSULIN-RESISTANCE; STEM EXTRACT; LIRAGLUTIDE; WEIGHT;

D O I：

10.1007/s10068-018-00551-y

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of this study was to investigate the combined effects of Diospyros lotus leaves extracts (DLE) and Muscat Bailey A grape stalk extracts (MGSE) in obesity induced by high-fat diet (HFD) in mice. The mice were fed with HFD and orally administered daily with DLE, MGSE, a mixture of DLE and MGSE, and Garcinia cambogia extract over a period of 16weeks. The results revealed that daily administration of DLE and MGSE mixtures markedly prevented HFD-induced weight gain, plasma lipid profile, hepatic steatosis, hepatic fibrosis, diabetic symptoms, and the risk of developing cardiovascular diseases. Also, DLE and MGSE mixtures administration greatly prevented oxidative stress and liver toxicity. The combined effects of DLE and MGSE mixtures were higher than effects of the single extracts and ofG. cambogia, a plant known for its anti-obesity effects. In summary, these findings demonstrated that DLE and MGSE mixtures, exhibit anti-obesity activity in HFD-fed mice.

引用

页码：1207 / 1215

页数：9

共 26 条

[1] Ultrasonically assisted antioxidant extraction from grape stalks and olive leaves [J].