The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus

被引：81
作者：
Full, Louise E.
Ruisanchez, Cristina
Monaco, Claudia [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst, London W6 8LH, England
来源：
ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 02期
关键词：
CORONARY-ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; RISK-FACTORS; INTIMA-MEDIA; HEART-DISEASE; ACCELERATES ATHEROSCLEROSIS; DENSITY-LIPOPROTEIN; AUTOIMMUNE-DISEASES; DEFICIENT MICE;
D O I：
10.1186/ar2631
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Pro-atherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgroups of patients with inflammatory diseases. Common molecular pathways shared by atherosclerosis and inflammatory disease may be involved. In this review we map the key determinants of the increased incidence of cardiovascular disease in patients with inflammatory diseases at each step of the atherogenesis.
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页数：10
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