Genetic polymorphisms and the development of invasive bacterial infections in children

被引：4

作者：

Esposito, Susanna ^{[1
]}

Bosis, Samantha ^{[1
]}

Orenti, Annalisa ^{[2
]}

Spena, Silvia ^{[1
]}

Montinaro, Valentina ^{[1
]}

Bianchini, Sonia ^{[1
]}

Zampiero, Alberto ^{[1
]}

Principi, Nicola ^{[1
]}

机构：

[1] Univ Milan, Dept Pathophysiol & Transplantat, Paediat Highly Intens Care Unit, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Commenda 9, I-20122 Milan, Italy

[2] Univ Milan, Unit Med Stat Biometry & Bioinformat GA Maccacaro, Dept Clin Sci & Community Hlth, Fdn IRCCS Ist Nazl Tumori, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2016年 / 29卷 / 01期

关键词：

adaptive immunity; genetic polymorphisms; innate immunity; invasive bacterial disease; Neisseria meningitidis; sepsis; Streptococcus pneumoniae; SUSCEPTIBILITY; SEPSIS; RISK; VARIANTS; SEVERITY; MALARIA; DISEASE; LEPROSY; TIRAP; ZINC;

D O I：

10.1177/0394632015622961

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the associations between single nucleotide polymorphisms (SNPs) of factors involved in the development of invasive bacterial disease (IBD) in children, 47 SNPs of 18 candidate genes were analysed in 49 children with IBD and 100 controls. The G/T genotype of TLR2 rs2149356 and the C genotype of LTA rs2229094 were associated with significantly reduced risk of developing IBD (P = 0.04 and P = 0.05, respectively), whereas the C/T genotype of RFP175 rs1585110 was associated with a significantly higher risk of developing IBD (P = 0.02). These results support the evidence that some genetic variants of factors involved in innate immunity may influence IBD risk in children.

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页码：99 / 104

页数：6

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