An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

被引：23

作者：

Boumoud, Taoues ^{[1
]}

Boumoud, Boudjemaa ^{[1
]}

Rhouati, Salah ^{[1
]}

Belfaitah, Ali ^{[1
]}

Debache, Abdelmadjid ^{[1
]}

Mosset, Paul ^{[2
]}

机构：

[1] Univ Mentouri Constantine, Fac Sci, Dept Chim, Lab Prod Nat Origine Vegetale & Synth Organ, Constantine 25000, Algeria

[2] ENSCR, CNRS, UMR 6226, F-35700 Rennes, France

来源：

E-JOURNAL OF CHEMISTRY | 2008年 / 5卷 / 04期

关键词：

Biginelli reaction; multi-component reactions (MCRs); Dihydropyrimidinones (DHPMs); Lead(II) nitrate; Scaffold; Leader file;

D O I：

10.1155/2008/132879

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)(2), as a recycling catalyst, from a diversity of aromatic aldehydes, beta-ketoesters and urea. The reaction was carried out in refluxing acetonitrile and afforded the target molecules in good to excellent yields. The method offers several advantages including high yields of the products, short reaction times and easy experimental workup procedure.

引用

页码：688 / 695

页数：8

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