Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery

被引：19

作者：

Jimenez-Agueero, Raul ^{[1
,2
]}

Emparanza, Jose I. ^{[2
]}

Beguiristain, Adolfo ^{[1
]}

Bujanda, Luis ^{[1
,3
]}

Alustiza, Jose M. ^{[1
,4
]}

Garcia, Elisabeth ^{[4
]}

Hijona, Elizabeth ^{[1
,3
]}

Gallego, Lander ^{[1
]}

Sanchez-Gonzalez, Javier ^{[5
]}

Perugorria, Maria J. ^{[1
,3
,6
]}

Asensio, Jose I. ^{[1
]}

Larburu, Santiago ^{[1
]}

Garmendia, Maddi ^{[7
]}

Larzabal, Mikel ^{[7
]}

Portillo, Maria P. ^{[8
]}

Aguirre, Leixuri ^{[8
]}

Banales, Jesus M. ^{[1
,3
,6
]}

机构：

[1] Univ Basque Country UPV EHU, Donostia Univ Hosp HUD, Biodonostia Res Inst, Dept Liver & Gastrointestinal Dis, San Sebastian, Spain

[2] Biodonostia Res Inst HUD, CASPe, CIBER ESP, Clin Epidemiol Unit, San Sebastian, Spain

[3] Natl Inst Study Liver & Gastrointestinal Dis CIBE, Barcelona, Spain

[4] Osatek SA, San Sebastian, Spain

[5] Philips Healthcare, Madrid, Spain

[6] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

[7] HUD, Dept Pathol, San Sebastian, Spain

[8] Univ Basque Country, CIBER Obn, Fac Pharm, Dept Nutr & Food Sci, Vitoria, Spain

来源：

BMC MEDICINE | 2014年 / 12卷

关键词：

Non-alcoholic fatty liver disease; Magnetic resonance imaging; Hepatic fat concentration; Obesity; Bariatric surgery; Diagnosis; FATTY LIVER-DISEASE; MAGNETIC-RESONANCE; QUANTITATIVE ASSESSMENT; NONALCOHOLIC STEATOHEPATITIS; STEATOSIS QUANTIFICATION; 1.5; T; SPECTROSCOPY; FRACTION; VARIABILITY; HISTOLOGY;

D O I：

10.1186/s12916-014-0137-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic at diagnosis, new non-invasive approaches are needed to determine the hepatic lipid content in terms of diagnosis, treatment and control of disease progression. Here, we investigated the potential of magnetic resonance imaging (MRI) to quantitate and monitor the hepatic triglyceride concentration in humans. Methods: A prospective study of diagnostic accuracy was conducted among 129 consecutive adult patients (97 obesity and 32 non-obese) to compare multi-echo MRI fat fraction, grade of steatosis estimated by histopathology, and biochemical measurement of hepatic triglyceride concentration (that is, Folch value). Results: MRI fat fraction positively correlates with the grade of steatosis estimated on a 0 to 3 scale by histopathology. However, this correlation value was stronger when MRI fat fraction was linked to the Folch value, resulting in a novel equation to predict the hepatic triglyceride concentration (mg of triglycerides/g of liver tissue = 5.082 + (432.104 * multi-echo MRI fat fraction)). Validation of this formula in 31 additional patients (24 obese and 7 controls) resulted in robust correlation between the measured and estimated Folch values. Multivariate analysis showed that none of the variables investigated improves the Folch prediction capacity of the equation. Obese patients show increased steatosis compared to controls using MRI fat fraction and Folch value. Bariatric surgery improved MRI fat fraction values and the Folch value estimated in obese patients one year after surgery. Conclusions: Multi-echo MRI is an accurate approach to determine the hepatic lipid concentration by using our novel equation, representing an economic non-invasive method to diagnose and monitor steatosis in humans.

引用

页数：14

共 27 条

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