Synthesis of a C3 Hydroxyproline-modified Carbapenem

被引：0
作者：
Valiullina, Z. R. [1 ]
Galeeva, A. M. [1 ]
Miftakhov, M. S. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, Ufa 450054, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 11期
关键词：
beta-lactam antibiotics; carbapenems; trans-4-l-hydroxyproline; carbapenemenol phosphate; 2-ethoxythiolanone;
D O I：
10.1134/S1070428022110173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl (4R)-4-hydroxy-1-(sulfanylacetyl)-l-prolinate was synthesized starting from trans-4-l-hydroxyprolinate methyl ester hydrochloride and then reacted with the known carbapenem enol phosphate to obtain the corresponding carbapenem and then to chemically more stable methyl ester.
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收藏
页码：1664 / 1667
页数：4
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