Immunomodulation: checkpoint blockade etc.

被引：28

作者：

Curry, William T. ^{[1
,2
]}

Lim, Michael ^{[3
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21287 USA

来源：

NEURO-ONCOLOGY | 2015年 / 17卷

关键词：

biomarker; checkpoint blockade; clinical trial; glioblastoma; immunotherapy; MONOCLONAL-ANTIBODIES; CTLA-4; IPILIMUMAB; MELANOMA; RADIATION; CELLS; PD-1; PEMBROLIZUMAB; COMBINATION; BIOMARKERS;

D O I：

10.1093/neuonc/nov174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune microenvironment is considered a major obstacle to generating an effective antitumor immune response. Checkpoint inhibitors manipulate the co-stimulatory response between antigen-presenting cells and immune cells-or between the tumor and immune cells-to elicit an antitumor immune response that would have otherwise been suppressed. Checkpoint inhibitors have shown great promise in the clinics, and some inhibitors such as anti-CTLA-4 antibodies and anti-PD-1 antibodies have gained FDA approval for certain tumors. Here we will discuss the current state of checkpoint inhibitors, biomarker strategies, and management of associated toxicities in glioblastoma.

引用

页码：26 / 31

页数：6

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