Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus

被引：14

作者：

Tseng, Cheng-Yin ^{[1
,2
]}

Sun, Mao-Feng ^{[3
,4
]}

Li, Tsai-Chung ^{[5
]}

Lin, Ching-Ting ^{[6
]}

机构：

[1] China Med Univ, Grad Inst Chinese Med, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[2] Hsinchu Mackay Mem Hosp, Infect Dis Sect, 690,Sec 2,Guang Fu Rd, Hsinchu 30071, Taiwan

[3] China Med Univ Hosp, Dept Chinese Med, 2 Yu De Rd, Taichung 40447, Taiwan

[4] China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[5] China Med Univ, Dept Publ Hlth, Coll Publ Hlth, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[6] China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; CHINESE HERBAL MEDICINES; NONTUBERCULOUS MYCOBACTERIA; SCUTELLARIA-BAICALENSIS; ANTIBACTERIAL ACTIVITY; INFECTIONS; BERBERINE; STRAINS; DISEASE;

D O I：

10.1155/2020/9754357

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Mycobacterium abscessus infections are notoriously difficult to be treated and newer treatment options are required. Coptis chinensis (C. chinensis) and its main compound berberine are frequently used to treat bacterial and viral infections. In this study, the susceptibility of M. abscessus to C. chinensis extract and berberine was assessed by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) evaluation. The effects of C. chinensis and berberine on biofilm formation and antibiotic susceptibility in M. abscessus were observed. C. chinensis at concentrations of MIC (1.5 mg/mL) and 2 x MIC (3.0 mg/mL) and berberine at 1/2 x MIC (0.125 mg/mL) demonstrated a strong inhibition of biofilm formation. Concentration of C. chinensis at 1/2 x MIC resulted in a significant reduction in MICs of trimethoprim/sulfamethoxazole (TMP/SXT), clarithromycin (CLA), and linezolid (LZD). Similarly, 1/2 x MIC berberine had a significant effect on the MIC reductions of nine antibiotics including TMP/SXT, CLA, and LZD. Notably, the resistance level MIC of LZD against M. abscessus was reversed to a susceptible level by treatment with either C. chinensis or berberine. Therefore, C. chinensis and berberine have the potential to produce a synergistic antimycobacterial effect, reduce biofilm formation, and decrease antibacterial resistance to LZD in M. abscessus.

引用

页数：9

共 45 条

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