Structural and Functional Connectivity of the Human Brain in Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder: A Rich Club-Organization Study

被引:124
作者
Ray, Siddharth [1 ,2 ]
Miller, Meghan [3 ]
Karalunas, Sarah [4 ]
Robertson, Charles [2 ]
Grayson, David S. [2 ,5 ]
Cary, Robert P. [2 ]
Hawkey, Elizabeth [2 ]
Painter, Julia G. [2 ]
Kriz, Daniel [2 ]
Fombonne, Eric [2 ,4 ,6 ,7 ]
Nigg, Joel T. [2 ,4 ]
Fair, Damien A. [2 ,4 ,8 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
[2] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[3] Calif State Univ Sacramento, Dept Psychiat & Behav Sci, Davis MIND Inst, Sacramento, CA 95819 USA
[4] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA
[5] Univ Calif Davis, Ctr Neurosci, Dept Psychiat, Davis, CA 95616 USA
[6] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97201 USA
[7] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97201 USA
[8] Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97201 USA
关键词
attention-deficit; hyperactivity disorder; autism spectrum disorders; high angular resolution diffusion imaging; rs-fMRI; connectivity; rich-club organization; DW-MRI; diffusion tensor imaging; DEFICIT HYPERACTIVITY DISORDER; DEFAULT-MODE NETWORK; SYMPTOM SEVERITY; CHILDREN; ABNORMALITIES; ADHD; SCHIZOPHRENIA; NEUROSCIENCE; SCHEDULE; VERSION;
D O I
10.1002/hbm.22603
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Attention-deficit/hyperactive disorder (ADHD) and autism spectrum disorders (ASD) are two of the most common and vexing neurodevelopmental disorders among children. Although the two disorders share many behavioral and neuropsychological characteristics, most MRI studies examine only one of the disorders at a time. Using graph theory combined with structural and functional connectivity, we examined the large-scale network organization among three groups of children: a group with ADHD (8-12 years, n=20), a group with ASD (7-13 years, n=16), and typically developing controls (TD) (8-12 years, n=20). We apply the concept of the rich-club organization, whereby central, highly connected hub regions are also highly connected to themselves. We examine the brain into two different network domains: (1) inside a rich-club network phenomena and (2) outside a rich-club network phenomena. The ASD and ADHD groups had markedly different patterns of rich club and non rich-club connections in both functional and structural data. The ASD group exhibited higher connectivity in structural and functional networks but only inside the rich-club networks. These findings were replicated using the autism brain imaging data exchange dataset with ASD (n=85) and TD (n=101). The ADHD group exhibited a lower generalized fractional anisotropy and functional connectivity inside the rich-club networks, but a higher number of axonal fibers and correlation coefficient values outside the rich club. Despite some shared biological features and frequent comorbity, these data suggest ADHD and ASD exhibit distinct large-scale connectivity patterns in middle childhood. Hum Brain Mapp 35:6032-6048, 2014. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:6032 / 6048
页数:17
相关论文
共 73 条
[61]   Network homogeneity reveals decreased integrity of default-mode network in ADHD [J].
Uddin, Lucina Q. ;
Kelly, A. M. Clare ;
Biswal, Bharat B. ;
Margulies, Daniel S. ;
Shehzad, Zarrar ;
Shaw, David ;
Ghaffari, Manely ;
Rotrosen, John ;
Adler, Lenard A. ;
Castellanos, F. Xavier ;
Milham, Michael P. .
JOURNAL OF NEUROSCIENCE METHODS, 2008, 169 (01) :249-254
[62]   Salience Network-Based Classification and Prediction of Symptom Severity in Children With Autism [J].
Uddin, Lucina Q. ;
Supekar, Kaustubh ;
Lynch, Charles J. ;
Khouzam, Amirah ;
Phillips, Jennifer ;
Feinstein, Carl ;
Ryali, Srikanth ;
Menon, Vinod .
JAMA PSYCHIATRY, 2013, 70 (08) :869-879
[63]   High-cost, high-capacity backbone for global brain communication [J].
van den Heuvel, Martijn P. ;
Kahn, Rene S. ;
Goni, Joaquin ;
Sporns, Olaf .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (28) :11372-11377
[64]   Rich-Club Organization of the Human Connectome [J].
van den Heuvel, Martijn P. ;
Sporns, Olaf .
JOURNAL OF NEUROSCIENCE, 2011, 31 (44) :15775-15786
[65]   Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis [J].
van den Heuvel, Martijn P. ;
Mandl, Rene C. W. ;
Stam, Cornelis J. ;
Kahn, Rene S. ;
Pol, Hilleke E. Hulshoff .
JOURNAL OF NEUROSCIENCE, 2010, 30 (47) :15915-15926
[66]   Diffusion tensor imaging in attention deficit/hyperactivity disorder: A systematic review and meta-analysis [J].
van Ewijk, Hanneke ;
Heslenfeld, Dirk J. ;
Zwiers, Marcel P. ;
Buitelaar, Jan K. ;
Oosterlaan, Jaap .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2012, 36 (04) :1093-1106
[67]   Comparing Brain Networks of Different Size and Connectivity Density Using Graph Theory [J].
van Wijk, Bernadette C. M. ;
Stam, Cornelis J. ;
Daffertshofer, Andreas .
PLOS ONE, 2010, 5 (10)
[68]   Reduced functional connectivity within and between 'social' resting state networks in autism spectrum conditions [J].
von dem Hagen, Elisabeth A. H. ;
Stoyanova, Raliza S. ;
Baron-Cohen, Simon ;
Calder, Andrew J. .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2013, 8 (06) :694-701
[69]   Dysmaturation of the Default Mode Network in Autism [J].
Washington, Stuart D. ;
Gordon, Evan M. ;
Brar, Jasmit ;
Warburton, Samantha ;
Sawyer, Alice T. ;
Wolfe, Amanda ;
Mease-Ference, Erin R. ;
Girton, Laura ;
Hailu, Ayichew ;
Mbwana, Juma ;
Gaillard, William D. ;
Kalbfleisch, M. Layne ;
VanMeter, John W. .
HUMAN BRAIN MAPPING, 2014, 35 (04) :1284-1296
[70]   Distortions and disconnections: Disrupted brain connectivity in autism [J].
Wass, Sam .
BRAIN AND COGNITION, 2011, 75 (01) :18-28