Fabrication of Graphene-isolated-Au-nanocrystal Nanostructures for Multimodal Cell Imaging and Photothermal-enhanced Chemotherapy

被引:96
作者
Bian, Xia [1 ]
Song, Zhi-Ling [1 ]
Qian, Yu [1 ]
Gao, Wei [1 ]
Cheng, Zhen-Qian [1 ]
Chen, Long [2 ]
Liang, Hao [1 ]
Ding, Ding [1 ]
Nie, Xiang-Kun [1 ]
Chen, Zhuo [1 ]
Tan, Weihong [1 ,3 ,4 ,5 ]
机构
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Collaborat Innovat Ctr Chem & Mol Med, Coll Chem & Chem Engn,Coll Biol,Mol Sci & Biomed, Changsha 410082, Hunan, Peoples R China
[2] Univ Macau, Fac Sci, Macau, Peoples R China
[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA
[4] Univ Florida, Dept Physiol & Funct Genom, Ctr Res Bio Nano Interface, Shands Canc Ctr,UF Genet Inst, Gainesville, FL 32611 USA
[5] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
基金
中国国家自然科学基金;
关键词
CARBON NANOTUBES; OXIDE NANOPARTICLES; GOLD NANOPARTICLES; LIVE CELLS; RAMAN; DNA; FLUORESCENCE; NANOTECHNOLOGY; SPECTROSCOPY; CHALLENGES;
D O I
10.1038/srep06093
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Using nanomaterials to develop multimodal systems has generated cutting-edge biomedical functions. Herein, we develop a simple chemical-vapor-deposition method to fabricate graphene-isolated-Au-nanocrystal (GIAN) nanostructures. A thin layer of graphene is precisely deposited on the surfaces of gold nanocrystals to enable unique capabilities. First, as surface-enhanced-Raman-scattering substrates, GIANs quench background fluorescence and reduce photocarbonization or photobleaching of analytes. Second, GIANs can be used for multimodal cell imaging by both Raman scattering and near-infrared (NIR) two-photon luminescence. Third, GIANs provide a platform for loading anticancer drugs such as doxorubicin (DOX) for therapy. Finally, their NIR absorption properties give GIANs photothermal therapeutic capability in combination with chemotherapy. Controlled release of DOX molecules from GIANs is achieved through NIR heating, significantly reducing the possibility of side effects in chemotherapy. The GIANs have high surface areas and stable thin shells, as well as unique optical and photothermal properties, making them promising nanostructures for biomedical applications.
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页数:9
相关论文
共 56 条
[1]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[2]   ADRIAMYCIN, 14-HYDROXYDAUNOMYCIN, A NEW ANTITUMOR ANTIBIOTIC FROM S-PEUCETIUS VAR CAESIUS [J].
ARCAMONE, F ;
CASSINEL.G ;
FANTINI, G ;
GREIN, A ;
OREZZI, P ;
POL, C ;
SPALLA, C .
BIOTECHNOLOGY AND BIOENGINEERING, 1969, 11 (06) :1101-&
[3]   Prospects and Challenges of Graphene in Biomedical Applications [J].
Bitounis, Dimitrios ;
Ali-Boucetta, Hanene ;
Hong, Byung Hee ;
Min, Dal-Hee ;
Kostarelos, Kostas .
ADVANCED MATERIALS, 2013, 25 (16) :2258-2268
[4]   Graphene Fluorescence Resonance Energy Transfer Aptasensor for the Thrombin Detection [J].
Chang, Haixin ;
Tang, Longhua ;
Wang, Ying ;
Jiang, Jianhui ;
Li, Jinghong .
ANALYTICAL CHEMISTRY, 2010, 82 (06) :2341-2346
[5]   Protein microarrays with carbon nanotubes as multicolor Raman labels [J].
Chen, Zhuo ;
Tabakman, Scott M. ;
Goodwin, Andrew P. ;
Kattah, Michael G. ;
Daranciang, Dan ;
Wang, Xinran ;
Zhang, Guangyu ;
Li, Xiaolin ;
Liu, Zhuang ;
Utz, Paul J. ;
Jiang, Kaili ;
Fan, Shoushan ;
Dai, Hongjie .
NATURE BIOTECHNOLOGY, 2008, 26 (11) :1285-1292
[6]  
Cho EC, 2011, NAT NANOTECHNOL, V6, P385, DOI [10.1038/NNANO.2011.58, 10.1038/nnano.2011.58]
[7]   Fabrication and Biofunctionalization of Carbon-Encapsulated Au Nanoparticles [J].
Chopra, Nitin ;
Bachas, Leonidas G. ;
Knecht, Marc R. .
CHEMISTRY OF MATERIALS, 2009, 21 (07) :1176-+
[8]   Cancer Nanomedicine: From Drug Delivery to Imaging [J].
Chow, Edward Kai-Hua ;
Ho, Dean .
SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (216)
[9]   The golden age: gold nanoparticles for biomedicine [J].
Dreaden, Erik C. ;
Alkilany, Alaaldin M. ;
Huang, Xiaohua ;
Murphy, Catherine J. ;
El-Sayed, Mostafa A. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2740-2779
[10]   Impact of Nanotechnology on Drug Delivery [J].
Farokhzad, Omid C. ;
Langer, Robert .
ACS NANO, 2009, 3 (01) :16-20