Decreased LINE-1 methylation levels in aldosterone-producing adenoma

被引：0
作者：
Chen, Chen [1 ]
Zhou, Xiaoyu [2 ]
Jing, Jing [1 ]
Cheng, Jing [1 ]
Luo, Yu [1 ]
Chen, Jiachao [1 ]
Xu, Xi [1 ]
Leng, Fei [1 ]
Li, Xiaomu [1 ]
Lu, Zhiqiang [1 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Endocrinol, Shanghai 200433, Peoples R China
[2] Inst Planned Parenthood Res, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 07期
关键词：
Long interspersed nuclear elements-1; global DNA methylation; aldosterone-producing adenoma; DNA METHYLATION; GENOMIC HYPOMETHYLATION; GLOBAL METHYLATION; NORMAL-TISSUES; BREAST-CANCER; BLOOD DNA; HYPERTENSION; ASSOCIATION; RISK; CARCINOGENESIS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Abnormal global DNA methylation levels are associated with many diseases. In this study, we examined long interspersed nuclear elements-1 (LINE-1) methylation as a biomarker for abnormal global DNA methylation and aldosterone-producing adenoma (APA). Methods: Tissues from 25 APA and 6 normal adrenal glands (NAs) were analyzed for LINE-1 methylation by real-time methylation-specific polymerase chain reaction. The estimated LINE-1 methylation level was then tested for correlation with the clinicopathologic parameters of APA patients. Results: The methylation index (MI) level for LINE-1 was 0.91 in NA samples and 0.77 in APA samples (P < 0.001). For the APA samples, there were no statistical correlations between the MI level and various clinicopathologic parameters such as gender (P = 0.07). Conclusion: LINE-1 methylation is significantly lower in APA samples than in NA samples. LINE-1 methylation is not correlated with the clinical characteristics of APA.
引用
收藏
页码：4104 / 4111
页数：8
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