3D Printing of Protein Models in an Undergraduate Laboratory: Leucine Zippers

被引：45

作者：

Meyer, Scott C. ^{[1
]}

机构：

[1] Benedictine Univ, Dept Chem, Lisle, IL 60532 USA

来源：

JOURNAL OF CHEMICAL EDUCATION | 2015年 / 92卷 / 12期

关键词：

Upper-Division Undergraduate; Biochemistry; Computer-Based Learning; Hands-On Learning/Manipulatives; Proteins/Peptides; Laboratory Computing/Interfacing; HAND-HELD MODELS; CRYSTAL-STRUCTURE; COILED COILS; ORDERED DNA; VISUALIZATION; MECHANISM;

D O I：

10.1021/acs.jchemed.5b00207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An upper-division undergraduate laboratory experiment is described that explores the structure/function relationship of protein domains, namely leucine zippers, through a molecular graphics computer program and physical models fabricated by 3D printing. By generating solvent accessible surfaces and color-coding hydrophobic, basic, and acidic amino acid residues, students are able to visualize noncovalent interactions that are important in protein folding and protein protein interactions.

引用

页码：2120 / 2125

页数：6

共 25 条

[1]

[Anonymous], 2014, MAKERBOT DESKTOP BET

[2] The Protein Data Bank [J].