In vitro effect of fibrinogen on Candida albicans germ tube formation

被引：2

作者：

Rodrigues, A ^{[1
]}

Vaz, CP

Mårdh, PA

Da Fonseca, AF

De Oliveira, JM

机构：

[1] Porto Sch Med, Dept Microbiol, P-4200 Oporto, Portugal

[2] Univ Porto, Inst Pathol & Mol Immunol, P-4100 Porto, Portugal

[3] Univ Porto, Porto Sch Med, Dept Gynecol, P-4100 Porto, Portugal

[4] Univ Lund Hosp, Dept Obstet & Gynecol, S-22185 Lund, Sweden

来源：

APMIS | 1999年 / 107卷 / 11期

关键词：

Candida albicans; germ tube formation; fibrinogen;

D O I：

10.1111/j.1699-0463.1999.tb01505.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen, The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated iu the presence of serial concentrations of fraction I, type TV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.

引用

页码：1020 / 1022

页数：3

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